Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IMPDH2 | P12268 | 1/20 | 0.44 |
| ▸ | IMPDH1 | P20839 | 1/20 | 0.44 |
| ▸ | BCHE | P06276 | 1/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | MAOA | P21397 | 2/20 | 0.39 |
| ▸ | MAOB | P27338 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | HPGDS | O60760 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | AR | P10275 | 3/20 | 0.36 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | CASP3 | P42574 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29194864 | 0.82 | MAOA (0.46) | IMPDH2IMPDH1BCHEACHEKDM4E | |
| SCHEMBL7369228 | 0.82 | IMPDH2 (0.45) | IMPDH2IMPDH1BCHEACHEKDM4E | |
| SCHEMBL3951905 | 0.79 | ALDH1A1 (0.42) | IMPDH2IMPDH1KDM4EUSP2ALDH1A1 | |
| SCHEMBL16428549 | 0.79 | POLB (0.49) | IMPDH2IMPDH1BCHEACHEKDM4E | |
| SCHEMBL9575280 | 0.75 | IMPDH2 (0.62) | IMPDH2IMPDH1BCHEACHEKDM4E | |
| SCHEMBL10338061 | 0.74 | TSHR (0.50) | KDM4EALDH1A1GAA | |
| SCHEMBL29373184 | 0.72 | MAPT (0.44) | KDM4EUSP2ALDH1A1SMN1; SMN2POLB | |
| SCHEMBL819594 | 0.72 | CA1 (0.50) | KDM4EALDH1A1GAAMAPT | |
| SCHEMBL29973162 | 0.72 | CA1 (0.50) | KDM4EALDH1A1GAAMAPT | |
| SCHEMBL17954514 | 0.72 | BCHE (0.41) | IMPDH2IMPDH1BCHEACHEKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7557237-B2 | Process for the synthesis of 3-(3-fluoro-4-hydroxyphenyl)-7-hydroxynaphthonitrile | WYETH (US) | 2009-07-07 | — | — | US | disclosed |
| EP-1663929-A2 | PROCESS FOR THE SYNTHESIS OF 3-(3-FLUORO-4-HYDROXYPHENYL)-7-HYDROXYNAPHTHONITRILE | Wyeth (US) | 2006-06-07 | — | — | EP | disclosed |
| WO-2005026105-A2 | PROCESS FOR THE SYNTHESIS OF 3-(3-FLUORO-4-HYDROXYPHENYL)-7-HYDROXYNAPHTHONITRILE | WYETH (US) | 2005-03-24 | — | — | WO | disclosed |
| US-20050054870-A1 | Process for the synthesis of 3-(3-fluoro-4-hydroxyphenyl)-7-hydroxynaphthonitrile | WYETH (US) | 2005-03-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050054870-A1 | Process for the synthesis of 3-(3-fluoro-4-hydroxyphenyl)-7-hydroxynaphthonitrile | HRH4, HRH1, HRH3 | IMPDH2 1809/4885IMPDH1 1247/4885BCHE 794/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.