Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIA2 | P42262 | 1/20 | 0.37 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.36 |
| ▸ | IKBKB | O14920 | 1/20 | 0.36 |
| ▸ | PPARG | P37231 | 2/20 | 0.36 |
| ▸ | PPARA | Q07869 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | BCL2 | P10415 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | FYN | P06241 | 2/20 | 0.35 |
| ▸ | IDO1 | P14902 | 1/20 | 0.35 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.35 |
| ▸ | WNT3A | P56704 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.34 |
| ▸ | CTSS | P25774 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21997278 | 0.77 | GRIA2 (0.50) | GRIA2BCL2ALDH1A1 | |
| SCHEMBL17626154 | 0.74 | TP53 (0.49) | LMNAALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL1915009 | 0.72 | IDO1 (0.45) | ALDH1A1MAPTMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL15214656 | 0.72 | BCL2 (0.53) | GRIA2LMNABCL2ALDH1A1 | |
| SCHEMBL6509671 | 0.71 | ALDH1A1 (0.46) | GRIA2ALDH1A1 | |
| SCHEMBL2302646 | 0.71 | BCL2 (0.56) | GRIA2LMNABCL2MAPTSMN1; SMN2 | |
| SCHEMBL2305032 | 0.70 | BCL2 (0.59) | GRIA2LMNABCL2 | |
| SCHEMBL24625337 | 0.69 | GRIA2 (0.42) | GRIA2ROCK1IKBKBLMNABCL2 | |
| SCHEMBL8415008 | 0.69 | GRIA2 (0.58) | GRIA2BCL2CYP3A4 | |
| SCHEMBL7228532 | 0.69 | RAB9A (0.51) | ALDH1A1MAPTMEN1KMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2010508-A1 | THIAZOL-GUANIDINE DERIVATIVES USEFUL AS A (BETA)- RELATED PATHOLOGIES | AstraZeneca AB (SE) | 2009-01-07 | — | — | EP | claimed |
| WO-2007120096-A1 | THIAZOL-GUANIDINE DERIVATIVES USEFUL AS A (BETA)- RELATED PATHOLOGIES | ASTRAZENECA AB (SE) | 2007-10-25 | — | — | WO | claimed |