Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 11/20 | 0.40 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | IDO1 | P14902 | 1/20 | 0.37 |
| ▸ | KEAP1 | Q14145 | 3/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20783314 | 1.00 | SRC (0.40) | SRCBRD4IDO1KEAP1CYP1A2 | |
| SCHEMBL8572979 | 0.90 | CYP1A2 (0.43) | SRCBRD4IDO1CYP1A2POLB | |
| SCHEMBL3947235 | 0.90 | CYP1A2 (0.43) | SRCBRD4IDO1CYP1A2POLB | |
| SCHEMBL19674208 | 0.87 | HSD17B10 (0.40) | SRCBRD4IDO1HSD11B1 | |
| SCHEMBL3389544 | 0.86 | JAK2 (0.38) | SRCBRD4IDO1HSD11B1 | |
| SCHEMBL263737 | 0.86 | JAK2 (0.38) | SRCBRD4IDO1HSD11B1 | |
| SCHEMBL19540703 | 0.86 | HSD11B1 (0.38) | SRCBRD4IDO1HSD11B1 | |
| SCHEMBL7800302 | 0.84 | ECE1 (0.37) | SRCBRD4HSD11B1 | |
| SCHEMBL7807928 | 0.82 | BRD4 (0.39) | SRCBRD4HSD11B1 | |
| SCHEMBL3952747 | 0.82 | BRD4 (0.39) | SRCBRD4HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090264431-A1 | NOVEL CATHEPSIN C INHIBITORS AND THEIR USE | GLAXO GROUP LIMITED (GB) | 2009-10-22 | — | — | US | disclosed |
| WO-2009026197-A1 | NOVEL CATHEPSIN C INHIBITORS AND THEIR USE | GLAXO GROUP LIMITED (GB) | 2009-02-26 | — | — | WO | disclosed |
| WO-2009026197-A1 | NOVEL CATHEPSIN C INHIBITORS AND THEIR USE | GLAXO GROUP LIMITED (GB) | 2009-02-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090264431-A1 | NOVEL CATHEPSIN C INHIBITORS AND THEIR USE | CTSB, CTSS, CTSF | SRC 3768/4885BRD4 2317/4885IDO1 3335/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.