Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 2/20 | 0.52 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.52 |
| ▸ | HTR1A | P08908 | 2/20 | 0.46 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.46 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.46 |
| ▸ | GBA1 | P04062 | 1/20 | 0.45 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.45 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.45 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.44 |
| ▸ | HRH1 | P35367 | 2/20 | 0.44 |
| ▸ | HTR2C | P28335 | 5/20 | 0.44 |
| ▸ | HPGDS | O60760 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | DAO | P14920 | 1/20 | 0.41 |
| ▸ | HTR6 | P50406 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tert-Butyl Formate SCHEMBL27772583 | 0.85 | GABRA1 (0.41) | GABRA1GABRB2HTR1ASLC6A2SLC6A4 | |
| Hydrochloric Acid SCHEMBL31583308 | 0.84 | HTR6 (0.46) | GABRA1GABRB2SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL2755238 | 0.78 | SLC6A2 (0.59) | HTR1ASLC6A2SLC6A4SLC6A3SLC18A3 | |
| Hydrochloric Acid SCHEMBL240186 | 0.77 | SLC6A2 (0.58) | HTR1ASLC6A2SLC6A4SLC6A3SLC18A3 | |
| SCHEMBL27772578 | 0.76 | SMO (0.42) | GABRA1GABRB2HPGDSGAA | |
| SCHEMBL5765721 | 0.76 | CCR5 (0.45) | GABRA1GABRB2HTR1ASLC6A2SLC6A4 | |
| Hydrochloric Acid SCHEMBL7664777 | 0.75 | GABRA1 (0.46) | GABRA1GABRB2HTR1ASLC6A2SLC6A4 | |
| Hydrochloric Acid SCHEMBL5762628 | 0.75 | GABRA1 (0.46) | GABRA1GABRB2HTR1ASLC6A2SLC6A4 | |
| SCHEMBL3941345 | 0.74 | HPGDS (0.50) | GABRA1GABRB2GABRG2GABRB3SLC18A3 | |
| SCHEMBL28239703 | 0.73 | ADORA2A (0.33) | GABRA1GABRB2SLC18A3SIGMAR1HTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110059981-A9 | New Pyridine Analogues V | ASTRAZENECA AB (SE) | 2011-03-10 | — | — | US | disclosed |
| US-20090318464-A1 | New Pyridine Analogues V | ASTRAZENECA AB (SE) | 2009-12-24 | — | — | US | disclosed |
| CN-101511815-A | New pyridine analogues | ASTRAZENECA AB (SE) | 2009-08-19 | — | — | CN | disclosed |
| EP-2041115-A1 | NEW PYRIDINE ANALOGUES | AstraZeneca AB (SE) | 2009-04-01 | — | — | EP | disclosed |
| US-20080032992-A1 | New Pyridine Analogues V | ASTRAZENECA AB (SE) | 2008-02-07 | — | — | US | disclosed |
| WO-2008004942-A1 | NEW PYRIDINE ANALOGUES | ASTRAZENECA AB (SE) | 2008-01-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090318464-A1 | New Pyridine Analogues V | P2RY12, P2RY11, P2RY13 | GABRA1 2164/4885GABRB2 2423/4885HTR1A 267/4885 |
| US-20080032992-A1 | New Pyridine Analogues V | P2RY12, P2RY11, P2RY4 | GABRA1 1322/4885GABRB2 2169/4885HTR1A 228/4885 |
| US-20110059981-A9 | New Pyridine Analogues V | P2RY12, P2RY11, P2RY13 | GABRA1 2164/4885GABRB2 2423/4885HTR1A 267/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.