Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADH1B | P00325 | 3/20 | 0.42 |
| ▸ | ADH1A | P07327 | 3/20 | 0.42 |
| ▸ | ADH7 | P40394 | 3/20 | 0.42 |
| ▸ | ADH1C | P00326 | 2/20 | 0.42 |
| ▸ | EPHX1 | P07099 | 3/20 | 0.41 |
| ▸ | ADH4 | P08319 | 1/20 | 0.41 |
| ▸ | GNAO1 | P09471 | 3/20 | 0.41 |
| ▸ | GNAI3 | P08754 | 2/20 | 0.41 |
| ▸ | GNAI1 | P63096 | 2/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.34 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.33 |
| ▸ | BCHE | P06276 | 1/20 | 0.33 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3947858 | 0.90 | EPHX1 (0.40) | ADH1BADH1AADH7ADH1CEPHX1 | |
| SCHEMBL3955898 | 0.87 | GNAO1 (0.48) | ADH1BADH1AADH7ADH1CEPHX1 | |
| SCHEMBL3947872 | 0.81 | SMN1; SMN2 (0.39) | EPHX1GNAO1HRH3SMN1; SMN2HSD11B1 | |
| SCHEMBL3949738 | 0.81 | GNAI3 (0.42) | GNAO1GNAI3GNAI1CHRM4SIGMAR1 | |
| SCHEMBL5651899 | 0.80 | — | — | |
| SCHEMBL3950651 | 0.80 | GNAI3 (0.41) | GNAO1GNAI3GNAI1HRH3CHRM4 | |
| SCHEMBL3933000 | 0.79 | ADH1B (0.53) | ADH1BADH1AADH7ADH1CEPHX1 | |
| SCHEMBL22856387 | 0.79 | SIGMAR1 (0.48) | EPHX1GNAO1HRH3SMN1; SMN2HSD11B1 | |
| SCHEMBL31273045 | 0.78 | HRH3 (0.46) | EPHX1GNAO1HRH3SMN1; SMN2HSD11B1 | |
| SCHEMBL28149564 | 0.78 | HRH3 (0.46) | EPHX1GNAO1HRH3SMN1; SMN2HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009024825-A1 | 2-PYRAZINYLBENZIMIDAZOLE DERIVATIVES AS RECEPTOR TYROSINE KINASE INHIBITORS | ASTRAZENECA AB (SE) | 2009-02-26 | — | — | WO | disclosed |