Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 1/20 | 0.38 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.38 |
| ▸ | PDCD1LG2 | Q9BQ51 | 2/20 | 0.37 |
| ▸ | CD274 | Q9NZQ7 | 2/20 | 0.37 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
| ▸ | P2RX7 | Q99572 | 3/20 | 0.35 |
| ▸ | HCRTR1 | O43613 | 3/20 | 0.35 |
| ▸ | HCRTR2 | O43614 | 3/20 | 0.35 |
| ▸ | MMP13 | P45452 | 1/20 | 0.35 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.34 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.34 |
| ▸ | HTR2C | P28335 | 2/20 | 0.34 |
| ▸ | HTR2B | P41595 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4025390 | 0.78 | OPRM1 (0.37) | OPRM1OPRD1OPRK1PDCD1LG2CD274 | |
| SCHEMBL3945116 | 0.71 | SIGMAR1 (0.36) | PDCD1LG2CD274HCRTR1HCRTR2MMP13 | |
| SCHEMBL2204952 | 0.68 | OPRM1 (0.42) | OPRM1OPRD1OPRK1HTR1ASLC6A4 | |
| SCHEMBL5503363 | 0.67 | MMP13 (0.36) | PDCD1LG2CD274MMP13HTR2CHTR2B | |
| SCHEMBL4024429 | 0.67 | OPRL1 (0.35) | PDCD1LG2CD274MMP13HTR2CHTR2B | |
| SCHEMBL4517793 | 0.66 | HSD11B1 (0.52) | OPRM1OPRD1OPRK1HTR1ASLC6A4 | |
| SCHEMBL5503919 | 0.66 | HTR1A (0.37) | OPRM1OPRD1OPRK1PDCD1LG2CD274 | |
| SCHEMBL474803 | 0.66 | OPRM1 (0.39) | OPRM1OPRD1OPRK1HTR1ASLC6A4 | |
| SCHEMBL5506443 | 0.65 | DPP4 (0.35) | OPRM1PDCD1LG2CD274P2RX7ALDH1A1 | |
| SCHEMBL5500218 | 0.65 | MMP13 (0.38) | PDCD1LG2CD274MMP13HTR2CHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2049475-A1 | CYCLOHEXYL SUBSTITUTED PYRROLIDINONES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1 | Eli Lilly & Company (US) | 2009-04-22 | — | — | EP | disclosed |
| WO-2007127704-A1 | CYCLOHEXYL SUBSTITUTED PYRROLIDINONES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1 | ELI LILLY AND COMPANY (US) | 2007-11-08 | — | — | WO | disclosed |