Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 4/20 | 0.43 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.43 |
| ▸ | DRD3 | P35462 | 2/20 | 0.43 |
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
| ▸ | DRD4 | P21917 | 1/20 | 0.43 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.41 |
| ▸ | CHRM3 | P20309 | 3/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | SCN1A | P35498 | 1/20 | 0.40 |
| ▸ | MTOR | P42345 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL2395810 | 0.98 | OPRM1 (0.42) | CYP1A2OPRM1DRD3DRD2DRD4 | |
| SCHEMBL27963558 | 0.84 | CHRM3 (0.55) | OPRM1DRD3DRD2DRD4CHRM2 | |
| SCHEMBL2395807 | 0.84 | OPRM1 (0.41) | CYP1A2OPRM1DRD3DRD2DRD4 | |
| SCHEMBL10683962 | 0.83 | CYP1A2 (0.46) | CYP1A2OPRM1DRD3DRD2DRD4 | |
| SCHEMBL4399206 | 0.81 | CYP1A2 (0.45) | CYP1A2OPRM1DRD3DRD2DRD4 | |
| SCHEMBL394169 | 0.80 | KCNN4 (0.55) | CYP1A2OPRM1DRD3DRD2DRD4 | |
| SCHEMBL379350 | 0.79 | CYP2C19 (0.44) | CYP1A2OPRM1DRD3DRD2DRD4 | |
| SCHEMBL1614867 | 0.79 | CYP2C19 (0.54) | CYP1A2OPRM1DRD3DRD2DRD4 | |
| Hydrochloric Acid SCHEMBL2861649 | 0.78 | CYP2C19 (0.55) | CYP1A2OPRM1DRD3DRD2DRD4 | |
| SCHEMBL31643504 | 0.76 | OPRM1 (0.41) | CYP1A2OPRM1DRD3DRD2DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 94 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114617850-A | Loperamide hydrochloride orally disintegrating tablet and preparation method thereof | 北京万全德众医药生物技术有限公司 | 2022-06-14 | — | — | CN | disclosed |
| CN-107913260-A | A kind of loperamide hydrochloride soft capsule and preparation method thereof | 华益药业科技(安徽)有限公司 | 2018-04-17 | — | — | CN | disclosed |
| CN-107890461-A | A kind of loperamide hydrochloride dispersible tablet and preparation method thereof | 华益药业科技(安徽)有限公司 | 2018-04-10 | — | — | CN | disclosed |
| CN-107744513-A | A kind of Loperamide hydrochloride capsules and preparation method thereof | 华益药业科技(安徽)有限公司 | 2018-03-02 | — | — | CN | disclosed |
| EP-2384768-B1 | Phenylpropionamide compounds and the use thereof | PURDUE PHARMA LP (US) | 2013-08-21 | — | — | EP | disclosed |
| US-8497287-B2 | Aminotetralin compounds as mu opioid receptor antagonists | THERAVANCE, INC. (US) | 2013-07-30 | — | — | US | disclosed |
| US-8481743-B2 | Phenylpropionamide compounds and the use thereof | PURDUE PHARMA L.P. (US) | 2013-07-09 | — | — | US | disclosed |
| US-8481743-B2 | Phenylpropionamide compounds and the use thereof | PURDUE PHARMA L.P. (US) | 2013-07-09 | — | — | US | disclosed |
| US-8481743-B2 | Phenylpropionamide compounds and the use thereof | PURDUE PHARMA L.P. (US) | 2013-07-09 | — | — | US | disclosed |
| US-20130040965-A1 | AMINOTETRALIN COMPOUNDS AS MU OPIOID RECEPTOR ANTAGONISTS | THERAVANCE, INC. (US) | 2013-02-14 | — | — | US | disclosed |
| WO-2004026836-A2 | 1-PYRIDIN-4-YL-UREA DERIVATIVES | ACTELION PHARMACEUTICALS LTD (CH) | 2004-04-01 | — | — | WO | disclosed |
| US-20040034104-A1 | 2,2-Diphenylbutanamide derivatives and medicines containing the same | SSP CO., LTD. (JP) | 2004-02-19 | — | — | US | disclosed |
| WO-2003101953-A2 | TRIAZASPIRO COMPOUNDS USEFUL FOR TREATING OR PREVENTING PAIN | EURO-CELTIQUE, S.A (LU) | 2003-12-11 | — | — | WO | disclosed |
| EP-1325912-A1 | 2,2-DIPHENYLBUTANAMIDE DERIVATIVES AND MEDICINES CONTAINING THE SAME | SSP Co., Ltd. (JP) | 2003-07-09 | — | — | EP | disclosed |
| US-6573282-B1 | Compositions for treatment of peripheral hyperalgesia are provided. The compositions contain an anti-hyperalgesia effective amount of one or more compounds that directly or indirectly interact with peripheral opiate receptors | ADOLOR CORPORATION | 2003-06-03 | — | — | US | disclosed |
| US-6362203-B1 | ANALGESICS | SSP CO., LTD (JP) | 2002-03-26 | — | — | US | disclosed |
| EP-1097924-A1 | 4-hydroxy-4-phenylpiperidine derivatives having -opioid agonist activity and pharmaceuticals containing the same | SSP Co., Ltd. (JP) | 2001-05-09 | — | — | EP | disclosed |
| US-5994372-A | ANTIDIARRHEA COMPOUND | REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1999-11-30 | — | — | US | disclosed |
| EP-0852494-A2 | PERIPHERALLY ACTIVE ANTI-HYPERALGESIC OPIATES | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1998-07-15 | — | — | EP | disclosed |
| WO-1997009973-A2 | PERIPHERALLY ACTIVE ANTI-HYPERALGESIC OPIATES | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1997-03-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130040965-A1 | AMINOTETRALIN COMPOUNDS AS MU OPIOID RECEPTOR ANTAGONISTS | OPRL1, OPRM1, OPRK1 | CYP1A2 321/4885OPRM1 2/4885DRD3 94/4885 |
| US-20040034104-A1 | 2,2-Diphenylbutanamide derivatives and medicines containing the same | OPRD1, OPRM1, OPRK1 | CYP1A2 262/4885OPRM1 2/4885DRD3 95/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.