Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 known ✓ | P35372 | 4/20 | 0.42 |
| ▸ | DRD3 known ✓ | P35462 | 2/20 | 0.42 |
| ▸ | DRD2 known ✓ | P14416 | 1/20 | 0.42 |
| ▸ | DRD4 known ✓ | P21917 | 1/20 | 0.42 |
| ▸ | CHRM2 known ✓ | P08172 | 3/20 | 0.40 |
| ▸ | CHRM1 known ✓ | P11229 | 3/20 | 0.40 |
| ▸ | CHRM3 known ✓ | P20309 | 3/20 | 0.40 |
| ▸ | SCN1A known ✓ | P35498 | 1/20 | 0.39 |
| ▸ | SCN2A known ✓ | Q99250 | 1/20 | 0.39 |
| ▸ | SIGMAR1 known ✓ | Q99720 | 1/20 | 0.39 |
| ▸ | SCN3A known ✓ | Q9NY46 | 1/20 | 0.39 |
| ▸ | KCNH2 known ✓ | Q12809 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL395172 | 0.98 | CYP1A2 (0.43) | OPRM1DRD3DRD2DRD4CYP1A2 | |
| SCHEMBL2395807 | 0.82 | OPRM1 (0.41) | OPRM1DRD3DRD2DRD4CYP1A2 | |
| SCHEMBL27963558 | 0.82 | CHRM3 (0.55) | OPRM1DRD3DRD2DRD4LMNA | |
| SCHEMBL10683962 | 0.81 | CYP1A2 (0.46) | OPRM1DRD3DRD2DRD4CYP1A2 | |
| Hydrochloric Acid SCHEMBL2861649 | 0.80 | CYP2C19 (0.55) | OPRM1DRD3DRD2DRD4CYP1A2 | |
| SCHEMBL4399206 | 0.79 | CYP1A2 (0.45) | OPRM1DRD3DRD2DRD4CYP1A2 | |
| SCHEMBL394169 | 0.78 | KCNN4 (0.55) | OPRM1DRD3DRD2DRD4CYP1A2 | |
| SCHEMBL379350 | 0.78 | CYP2C19 (0.44) | OPRM1DRD3DRD2DRD4CYP1A2 | |
| SCHEMBL1614867 | 0.78 | CYP2C19 (0.54) | OPRM1DRD3DRD2DRD4CYP1A2 | |
| Hydrochloric Acid SCHEMBL11807083 | 0.77 | CYP3A4 (0.59) | OPRM1DRD3DRD2DRD4CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2384768-B1 | Phenylpropionamide compounds and the use thereof | PURDUE PHARMA LP (US) | 2013-08-21 | — | — | EP | disclosed |
| US-8481743-B2 | Phenylpropionamide compounds and the use thereof | PURDUE PHARMA L.P. (US) | 2013-07-09 | — | — | US | disclosed |
| EP-2079485-B1 | PHENYLPROPIONAMIDE COMPOUNDS AND THE USE THEREOF | PURDUE PHARMA LP (US) | 2012-06-13 | — | — | EP | disclosed |
| EP-2384768-A1 | Phenylpropionamide compounds and the use thereof | Purdue Pharma LP (US) | 2011-11-09 | — | — | EP | disclosed |
| US-8039636-B2 | Methods for making 4-tetrazolyl-4-phenylpiperidine compounds | PURDUE PHARMA L.P. (US) | 2011-10-18 | — | — | US | disclosed |
| US-8026254-B2 | Therapeutic agents useful for treating pain | PURDUE PHARMA, L.P. (US) | 2011-09-27 | — | — | US | disclosed |
| US-20100234426-A1 | Phenylpropionamide Compounds and the Use Thereof | PURDUE PHARMA L.P. (US) | 2010-09-16 | — | — | US | disclosed |
| US-7687518-B2 | Therapeutic agents useful for treating pain | PURDUE PHARMA L.P. (US) | 2010-03-30 | — | — | US | disclosed |
| US-20100069437-A1 | THERAPEUTIC AGENTS USEFUL FOR TREATING PAIN | PURDUE PHARMA L.P. (US) | 2010-03-18 | — | — | US | disclosed |
| US-20090240056-A1 | METHODS FOR MAKING 4-TETRAZOLYL-4-PHENYLPIPERIDINE COMPOUNDS | EURO-CELTIQUE S.A. (LU) | 2009-09-24 | — | — | US | disclosed |
| US-20070179141-A1 | Therapeutic agents useful for treating pain | EURO-CELTIQUE S.A. | 2007-08-02 | — | — | US | disclosed |
| EP-1803718-A1 | 4-Tetrazolyl-4-phenylpiperidine derivatives for treating pain | Euro-Celtique, S.A. (LU) | 2007-07-04 | — | — | EP | disclosed |
| US-7202259-B2 | Therapeutic agents useful for treating pain | EURO-CELTIQUE S.A. (LU) | 2007-04-10 | — | — | US | disclosed |
| EP-1562932-B1 | 4-TETRAZOLYL-4-PHENYLPIPERIDINE DERIVATIVES FOR TREATING PAIN | EURO CELTIQUE SA (LU) | 2007-04-04 | — | — | EP | disclosed |
| US-20070072909-A1 | deblocking, deprotecting; debenzylation; for preventing pain, diarrhea | EURO-CELTIQUE S.A. | 2007-03-29 | — | — | US | disclosed |
| EP-1709029-A2 | METHODS FOR MAKING 4-TETRAZOLYL-4-PHENYLPIPERIDINE COMPOUNDS | EURO-CELTIQUE S.A. (LU) | 2006-10-11 | — | — | EP | disclosed |
| WO-2005075455-A2 | METHODS FOR MAKING 4-TETRAZOLYL-4-PHENYLPIPERIDINE COMPOUNDS | EURO-CELTIQUE S.A. (LU) | 2005-08-18 | — | — | WO | disclosed |
| EP-1562932-A1 | 4-TETRAZOLYL-4-PHENYLPIPERIDINE DERIVATIVES FOR TREATING PAIN | Euro-Celtique, S.A. (LU) | 2005-08-17 | — | — | EP | disclosed |
| US-20040152689-A1 | Therapeutic agents useful for treating pain | EURO-CELTIQUE, S.A. | 2004-08-05 | — | — | US | disclosed |
| WO-2004046132-A1 | 4-TETRAZOLYL-4PHENYLPIPERIDINE DERIVATIVES FOR TREATING PAIN | EURO-CELTIQUE, S.A. (LU) | 2004-06-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070179141-A1 | Therapeutic agents useful for treating pain | OPRL1, OPRK1, OGFR | OPRM1 4/4885DRD3 1608/4885DRD2 994/4885 |
| US-20100069437-A1 | THERAPEUTIC AGENTS USEFUL FOR TREATING PAIN | OPRL1, OPRK1, OGFR | OPRM1 4/4885DRD3 1608/4885DRD2 994/4885 |
| US-20040152689-A1 | Therapeutic agents useful for treating pain | OPRL1, OPRK1, OGFR | OPRM1 4/4885DRD3 1608/4885DRD2 994/4885 |
| US-20100234426-A1 | Phenylpropionamide Compounds and the Use Thereof | OPRL1, OPRK1, OPRD1 | OPRM1 4/4885DRD3 242/4885DRD2 200/4885 |
| US-20070072909-A1 | deblocking, deprotecting; debenzylation; for preventing pain, diarrhea | OPRL1, DECR1, PKD1 | OPRM1 250/4885DRD3 7/4885DRD2 32/4885 |
| US-20090240056-A1 | METHODS FOR MAKING 4-TETRAZOLYL-4-PHENYLPIPERIDINE COMPOUNDS | NAT1, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, AHR | OPRM1 211/4885DRD3 62/4885DRD2 152/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.