Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 7/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.47 |
| ▸ | CDC25B | P30305 | 7/20 | 0.47 |
| ▸ | MAPT | P10636 | 6/20 | 0.47 |
| ▸ | CDC25A | P30304 | 6/20 | 0.47 |
| ▸ | LMNA | P02545 | 4/20 | 0.47 |
| ▸ | IDO1 | P14902 | 4/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | HPGD | P15428 | 4/20 | 0.47 |
| ▸ | BLM | P54132 | 4/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.47 |
| ▸ | TP53 | P04637 | 3/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.47 |
| ▸ | PKM | P14618 | 2/20 | 0.47 |
| ▸ | PLIN1 | O60240 | 2/20 | 0.47 |
| ▸ | MAOA | P21397 | 2/20 | 0.47 |
| ▸ | PLIN5 | Q00G26 | 2/20 | 0.47 |
| ▸ | ABHD5 | Q8WTS1 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL216842 | 0.81 | LMNA (0.36) | MEN1KMT2ACDC25BMAPTCDC25A | |
| SCHEMBL27389227 | 0.79 | LMNA (0.35) | MEN1KMT2ACDC25BMAPTCDC25A | |
| SCHEMBL678100 | 0.77 | MAPT (0.61) | MEN1KMT2ACDC25BMAPTCDC25A | |
| SCHEMBL28865587 | 0.74 | LMNA (0.31) | LMNAACHE | |
| SCHEMBL28249231 | 0.74 | LMNA (0.31) | LMNAACHE | |
| SCHEMBL27499719 | 0.74 | LMNA (0.31) | LMNAACHE | |
| SCHEMBL30715504 | 0.71 | CDC25B (0.57) | MEN1KMT2ACDC25BMAPTCDC25A | |
| SCHEMBL8773107 | 0.71 | CDC25B (0.57) | MEN1KMT2ACDC25BMAPTCDC25A | |
| Formic Acid SCHEMBL31606783 | 0.69 | MAPT (0.52) | MEN1KMT2ACDC25BMAPTCDC25A | |
| SCHEMBL10885342 | 0.68 | CDC25B (0.44) | MEN1KMT2ACDC25BMAPTCDC25A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8101649-B2 | N-acylhydrazone derivatives useful as modulators of nicotinic acetylcholine receptors | NEUROSEARCH A/S (DK) | 2012-01-24 | — | — | US | disclosed |
| US-20100280092-A1 | N-ACYLHYDRAZONE DERIVATIVES USEFUL AS MODULATORS OF NICOTINIC ACETYLCHOLINE RECEPTORS | NEUROSEARCH A/S (DK) | 2010-11-04 | — | — | US | disclosed |
| EP-2212285-A1 | N-ACYLHYDRAZONE DERIVATIVES USEFUL AS MODULATORS OF NICOTINIC ACETYLCHOLINE RECEPTORS | NeuroSearch A/S (DK) | 2010-08-04 | — | — | EP | disclosed |
| WO-2009065854-A1 | N-ACYLHYDRAZONE DERIVATIVES USEFUL AS MODULATORS OF NICOTINIC ACETYLCHOLINE RECEPTORS | NEUROSEARCH A/S (DK) | 2009-05-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100280092-A1 | N-ACYLHYDRAZONE DERIVATIVES USEFUL AS MODULATORS OF NICOTINIC ACETYLCHOLINE RECEPTORS | CHRNA3, CHRNA6, CHRNA2 | MEN1 4049/4885KMT2A 1615/4885CDC25B 4363/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.