Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GNAI3 | P08754 | 2/20 | 0.41 |
| ▸ | GNAO1 | P09471 | 2/20 | 0.41 |
| ▸ | GNAI1 | P63096 | 2/20 | 0.41 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.36 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.34 |
| ▸ | ACHE | P22303 | 3/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.33 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.33 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.33 |
| ▸ | BCHE | P06276 | 2/20 | 0.33 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.33 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.33 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.33 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.33 |
| ▸ | CACNA1I | Q9P0X4 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3948572 | 0.90 | GNAO1 (0.42) | GNAI3GNAO1GNAI1SLC6A5ACHE | |
| SCHEMBL3949738 | 0.90 | GNAI3 (0.42) | GNAI3GNAO1GNAI1SLC18A3SLC6A5 | |
| SCHEMBL3947113 | 0.83 | GNAO1 (0.47) | GNAI3GNAO1GNAI1ACHECARM1 | |
| SCHEMBL3950651 | 0.83 | GNAI3 (0.41) | GNAI3GNAO1GNAI1SLC6A5ACHE | |
| SCHEMBL3956282 | 0.81 | SLC18A3 (0.39) | SLC18A3ACHEPKMKMT2ACHRM2 | |
| SCHEMBL3947858 | 0.79 | EPHX1 (0.40) | GNAI3GNAO1GNAI1HTR4CHRM4 | |
| SCHEMBL3947826 | 0.79 | NCF1 (0.42) | GNAI3GNAO1GNAI1ACHE | |
| SCHEMBL3956952 | 0.78 | CHRM1 (0.38) | GNAO1SLC18A3ACHECHRM2CHRM4 | |
| SCHEMBL17754051 | 0.77 | KDM1A (0.34) | GNAI3GNAO1GNAI1ACHECHRM4 | |
| SCHEMBL3955867 | 0.77 | KMT2A (0.36) | SLC18A3SLC6A5ACHEPKMKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009024825-A1 | 2-PYRAZINYLBENZIMIDAZOLE DERIVATIVES AS RECEPTOR TYROSINE KINASE INHIBITORS | ASTRAZENECA AB (SE) | 2009-02-26 | — | — | WO | disclosed |