Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GNAI3 | P08754 | 2/20 | 0.41 |
| ▸ | GNAO1 | P09471 | 2/20 | 0.41 |
| ▸ | GNAI1 | P63096 | 2/20 | 0.41 |
| ▸ | CHRM4 | P08173 | 9/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 8/20 | 0.40 |
| ▸ | CHRM5 | P08912 | 8/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 8/20 | 0.40 |
| ▸ | CHRM3 | P20309 | 8/20 | 0.40 |
| ▸ | DRD2 | P14416 | 4/20 | 0.40 |
| ▸ | DRD4 | P21917 | 4/20 | 0.40 |
| ▸ | DRD3 | P35462 | 3/20 | 0.40 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.36 |
| ▸ | ACHE | P22303 | 2/20 | 0.36 |
| ▸ | BCHE | P06276 | 1/20 | 0.36 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | CCR3 | P51677 | 1/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.34 |
| ▸ | HTR1A | P08908 | 1/20 | 0.34 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3949738 | 0.92 | GNAI3 (0.42) | GNAI3GNAO1GNAI1CHRM4CHRM2 | |
| SCHEMBL3948572 | 0.92 | GNAO1 (0.42) | GNAI3GNAO1GNAI1CHRM4CHRM2 | |
| SCHEMBL3955898 | 0.83 | GNAO1 (0.48) | GNAI3GNAO1GNAI1CHRM4CHRM2 | |
| SCHEMBL3955872 | 0.83 | GNAI3 (0.41) | GNAI3GNAO1GNAI1CHRM4CHRM2 | |
| SCHEMBL3947168 | 0.83 | CHRM1 (0.42) | GNAO1CHRM4CHRM2CHRM5CHRM1 | |
| SCHEMBL3949394 | 0.82 | ALDH1A1 (0.41) | GNAI3GNAO1GNAI1CHRM4CHRM2 | |
| SCHEMBL3949507 | 0.82 | ADH1B (0.39) | GNAI3GNAO1GNAI1ALDH1A1 | |
| SCHEMBL3950912 | 0.81 | CHRM1 (0.40) | GNAO1CHRM4CHRM2CHRM5CHRM1 | |
| SCHEMBL4045148 | 0.80 | ADH1B (0.42) | GNAI3GNAO1GNAI1CHRM4CHRM2 | |
| SCHEMBL3950841 | 0.79 | ALDH1A1 (0.39) | GNAI3GNAO1GNAI1CHRM4CHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009024825-A1 | 2-PYRAZINYLBENZIMIDAZOLE DERIVATIVES AS RECEPTOR TYROSINE KINASE INHIBITORS | ASTRAZENECA AB (SE) | 2009-02-26 | — | — | WO | disclosed |