Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | ACHE | P22303 | 1/20 | 0.33 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.33 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.33 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.33 |
| ▸ | CACNA1I | Q9P0X4 | 1/20 | 0.33 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.32 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.32 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.32 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.32 |
| ▸ | DRD2 | P14416 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3948571 | 0.90 | CHRM4 (0.38) | ALDH1A1SMYD3SLC6A5ACHECHRM2 | |
| SCHEMBL3949734 | 0.90 | SIGMAR1 (0.37) | KMT2APKMSLC18A3ALDH1A1KDM4E | |
| SCHEMBL3947111 | 0.83 | GNAO1 (0.39) | ALDH1A1CARM1PRMT6CHRM2CHRM4 | |
| SCHEMBL3950649 | 0.83 | CHRM1 (0.40) | ALDH1A1SLC6A5ACHECHRM2CHRM4 | |
| SCHEMBL3949628 | 0.80 | ALDH1A1 (0.43) | KMT2APKMALDH1A1KDM4ELMNA | |
| SCHEMBL3947855 | 0.79 | HRH3 (0.41) | KMT2AKDM4ESMYD3SMN1; SMN2HSD11B1 | |
| SCHEMBL3947825 | 0.79 | NCF1 (0.42) | ACHE | |
| SCHEMBL3956278 | 0.77 | SLC18A3 (0.39) | KMT2APKMSLC18A3ALDH1A1KDM4E | |
| SCHEMBL3954098 | 0.77 | ALDH1A1 (0.41) | KMT2APKMALDH1A1KDM4ELMNA | |
| SCHEMBL3955872 | 0.77 | GNAI3 (0.41) | KMT2APKMSLC18A3SLC6A5ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009024825-A1 | 2-PYRAZINYLBENZIMIDAZOLE DERIVATIVES AS RECEPTOR TYROSINE KINASE INHIBITORS | ASTRAZENECA AB (SE) | 2009-02-26 | — | — | WO | disclosed |