Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | DRD1 | P21728 | 1/20 | 0.41 |
| ▸ | DRD4 | P21917 | 1/20 | 0.41 |
| ▸ | DRD5 | P21918 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | ESR1 | P03372 | 1/20 | 0.38 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.38 |
| ▸ | CNR1 | P21554 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1111733 | 0.87 | KDM4E (0.47) | KDM4ENPC1RAB9APOLBL3MBTL1 | |
| SCHEMBL1111945 | 0.76 | KDM4E (0.43) | KDM4EPOLBL3MBTL1DRD1DRD4 | |
| SCHEMBL1111731 | 0.76 | KDM4E (0.45) | KDM4EPOLBL3MBTL1DRD1DRD4 | |
| SCHEMBL29415418 | 0.68 | HTR7 (0.69) | ALDH1A1MEN1KMT2ACYP3A4CYP2D6 | |
| SCHEMBL28195866 | 0.68 | HTR7 (0.69) | ALDH1A1MEN1KMT2ACYP3A4CYP2D6 | |
| SCHEMBL14028115 | 0.68 | LTA4H (0.46) | KDM4ENPC1RAB9APOLBDRD1 | |
| SCHEMBL13503692 | 0.66 | OPRM1 (0.45) | KDM4ENPC1RAB9APOLBDRD1 | |
| SCHEMBL11120309 | 0.65 | SIGMAR1 (0.79) | ALDH1A1MEN1KMT2ACYP1A2CYP3A4 | |
| SCHEMBL4857927 | 0.65 | USP2 (0.88) | KDM4EPOLBL3MBTL1USP2ALDH1A1 | |
| SCHEMBL11663287 | 0.64 | USP2 (0.81) | KDM4EPOLBL3MBTL1USP2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009143246-A2 | ARYLSULFONAMIDE COMPOUNDS, COMPOSITIONS AND METHODS OF USE | GENENTECH, INC. (US) | 2009-11-26 | — | — | WO | disclosed |