Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE8A | O60658 | 2/20 | 0.43 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | YTHDC1 | Q96MU7 | 1/20 | 0.39 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3958861 | 0.91 | PDE8A (0.43) | PDE8AADORA3YTHDC1 | |
| SCHEMBL3955318 | 0.90 | ADORA3 (0.42) | ADORA3P2RX3 | |
| SCHEMBL3956271 | 0.88 | HDAC6 (0.42) | PDE8AADORA3TP53CYP1A2CYP3A4 | |
| SCHEMBL3960757 | 0.88 | CNR2 (0.46) | ADORA3YTHDC1 | |
| SCHEMBL3959345 | 0.86 | SLC29A1 (0.38) | ADORA3P2RX3 | |
| SCHEMBL3963832 | 0.85 | PDE4A (0.43) | PDE8AADORA3YTHDC1 | |
| SCHEMBL3954593 | 0.84 | CNR2 (0.43) | ADORA3 | |
| SCHEMBL3964659 | 0.84 | ADORA3 (0.39) | PDE8AADORA3 | |
| SCHEMBL3963350 | 0.84 | YTHDC1 (0.51) | PDE8AYTHDC1 | |
| SCHEMBL3955111 | 0.84 | ADORA3 (0.41) | PDE8AADORA3YTHDC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009034386-A1 | DERIVATIVES OF ADENINE AND 8-AZA-ADENINE AND USES THEREOF-796 | ASTRAZENECA AB (SE) | 2009-03-19 | — | — | WO | claimed |
| WO-2009034386-A1 | DERIVATIVES OF ADENINE AND 8-AZA-ADENINE AND USES THEREOF-796 | ASTRAZENECA AB (SE) | 2009-03-19 | — | — | WO | disclosed |