Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 3/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.33 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.33 |
| ▸ | TRPV4 | Q9HBA0 | 4/20 | 0.33 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | SLC2A2 | P11168 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3967596 | 0.91 | PTGDR2 (0.50) | PTGDR2AKR1C3AKR1C2TRPV4TRPM8 | |
| SCHEMBL3965620 | 0.86 | PTGDR2 (0.54) | PTGDR2 | |
| SCHEMBL3969463 | 0.83 | PTGDR2 (0.47) | PTGDR2MEN1KMT2APTGS2MAPT | |
| SCHEMBL3962099 | 0.78 | PTGDR2 (0.40) | PTGDR2AKR1C3AKR1C2PTGS2MAPT | |
| SCHEMBL3964361 | 0.78 | CYP3A4 (0.36) | PTGDR2MAPT | |
| SCHEMBL3973023 | 0.77 | PTGDR2 (0.66) | PTGDR2 | |
| SCHEMBL3967149 | 0.75 | RAPGEF4 (0.42) | PTGDR2AKR1C3AKR1C2KMT2APOLB | |
| SCHEMBL3968063 | 0.75 | HTR6 (0.34) | PTGDR2AKR1C3AKR1C2POLBSMN1; SMN2 | |
| SCHEMBL3962084 | 0.74 | PTGDR2 (0.39) | PTGDR2MEN1KMT2APTGS2KDM4E | |
| SCHEMBL3969206 | 0.74 | SLC6A4 (0.37) | PTGDR2MEN1KMT2APOLBPTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009044147-A1 | INDOLIZINE DERIVATIVES WITH CRTH2 RECEPTOR AFFINITY FOR THE TREATMENT OF INFLAMMATORY DISEASES | ARGENTA DISCOVERY LIMITED (GB) | 2009-04-09 | — | — | WO | disclosed |