Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.42 |
| ▸ | RAPGEF4 | Q8WZA2 | 5/20 | 0.34 |
| ▸ | HTR6 | P50406 | 2/20 | 0.34 |
| ▸ | PPME1 | Q9Y570 | 4/20 | 0.33 |
| ▸ | APEH | P13798 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3967967 | 0.91 | PTGDR2 (0.36) | PTGDR2RAPGEF4PPME1POLB | |
| SCHEMBL3968540 | 0.91 | PTGDR2 (0.47) | PTGDR2RAPGEF4HTR6PPME1APEH | |
| SCHEMBL3968600 | 0.82 | PTGDR2 (0.41) | PTGDR2RAPGEF4HTR6PPME1 | |
| SCHEMBL3973994 | 0.82 | PTGDR2 (0.40) | PTGDR2RAPGEF4HTR6PPME1APEH | |
| SCHEMBL4636239 | 0.79 | PTGDR2 (0.35) | PTGDR2ALDH1A1 | |
| SCHEMBL3968885 | 0.77 | PPME1 (0.37) | PTGDR2RAPGEF4HTR6PPME1ALDH1A1 | |
| SCHEMBL3332006 | 0.76 | MAPK1 (0.43) | L3MBTL1MEN1ALDH1A1MAPK1KMT2A | |
| SCHEMBL4636111 | 0.76 | MAPT (0.38) | L3MBTL1MEN1ALDH1A1POLBMAPK1 | |
| SCHEMBL3967733 | 0.75 | PTGDR2 (0.40) | PTGDR2RAPGEF4PPME1MEN1ALDH1A1 | |
| SCHEMBL3967149 | 0.75 | RAPGEF4 (0.42) | PTGDR2RAPGEF4PPME1L3MBTL1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009044134-A1 | INDOLIZINE DERIVATIVES WITH CRTH2 RECEPTOR AFFINITY FOR THE TREATMENT OF INFLAMMATORY DISEASES | ARGENTA DISCOVERY LIMITED (GB) | 2009-04-09 | — | — | WO | disclosed |