Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 3/20 | 0.40 |
| ▸ | RAPGEF4 | Q8WZA2 | 3/20 | 0.35 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.34 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | PPME1 | Q9Y570 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | KDM1A | O60341 | 1/20 | 0.32 |
| ▸ | MAOA | P21397 | 1/20 | 0.32 |
| ▸ | MAOB | P27338 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.32 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.32 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3968885 | 0.95 | PPME1 (0.37) | PTGDR2RAPGEF4PPME1ALDH1A1 | |
| SCHEMBL3973994 | 0.93 | PTGDR2 (0.40) | PTGDR2RAPGEF4PPME1MEN1KMT2A | |
| SCHEMBL3967149 | 0.92 | RAPGEF4 (0.42) | PTGDR2RAPGEF4NOD2NOD1PPME1 | |
| SCHEMBL3967117 | 0.92 | POLB (0.36) | PTGDR2RAPGEF4PPME1 | |
| SCHEMBL3967602 | 0.91 | RAPGEF4 (0.34) | PTGDR2RAPGEF4PPME1 | |
| SCHEMBL3974788 | 0.90 | PTGDR2 (0.46) | PTGDR2RAPGEF4PPME1 | |
| SCHEMBL3967784 | 0.90 | RAPGEF4 (0.35) | PTGDR2RAPGEF4PPME1MEN1KMT2A | |
| SCHEMBL3968063 | 0.87 | HTR6 (0.34) | PTGDR2RAPGEF4PPME1ALDH1A1 | |
| SCHEMBL3970978 | 0.87 | PTGDR2 (0.49) | PTGDR2RAPGEF4NOD2NOD1NPSR1 | |
| SCHEMBL3964361 | 0.85 | CYP3A4 (0.36) | PTGDR2RAPGEF4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009044147-A1 | INDOLIZINE DERIVATIVES WITH CRTH2 RECEPTOR AFFINITY FOR THE TREATMENT OF INFLAMMATORY DISEASES | ARGENTA DISCOVERY LIMITED (GB) | 2009-04-09 | — | — | WO | disclosed |