Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | RAPGEF4 | Q8WZA2 | 4/20 | 0.33 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.32 |
| ▸ | TRPV4 | Q9HBA0 | 4/20 | 0.32 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.32 |
| ▸ | ELANE | P08246 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
| ▸ | PPME1 | Q9Y570 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3968600 | 0.91 | PTGDR2 (0.41) | PTGDR2RAPGEF4DDR1TRPV4PPME1 | |
| SCHEMBL3963643 | 0.91 | PTGDR2 (0.42) | PTGDR2POLBRAPGEF4PPME1 | |
| SCHEMBL3967117 | 0.83 | POLB (0.36) | PTGDR2POLBRAPGEF4DDR1HIF1A | |
| SCHEMBL3968540 | 0.81 | PTGDR2 (0.47) | PTGDR2RAPGEF4PPME1 | |
| SCHEMBL13881877 | 0.79 | PTGDR2 (0.42) | PTGDR2RAPGEF4DDR1 | |
| SCHEMBL4636239 | 0.77 | PTGDR2 (0.35) | PTGDR2 | |
| SCHEMBL3968885 | 0.75 | PPME1 (0.37) | PTGDR2POLBRAPGEF4ELANEPPME1 | |
| SCHEMBL3969343 | 0.75 | PTGDR2 (0.39) | PTGDR2RAPGEF4PPME1 | |
| SCHEMBL3967784 | 0.75 | RAPGEF4 (0.35) | PTGDR2POLBRAPGEF4PPME1 | |
| SCHEMBL3967733 | 0.74 | PTGDR2 (0.40) | PTGDR2RAPGEF4PPME1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009044134-A1 | INDOLIZINE DERIVATIVES WITH CRTH2 RECEPTOR AFFINITY FOR THE TREATMENT OF INFLAMMATORY DISEASES | ARGENTA DISCOVERY LIMITED (GB) | 2009-04-09 | — | — | WO | disclosed |