Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 9/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | F2 | P00734 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | CASR | P41180 | 5/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | MC4R | P32245 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4970054 | 0.90 | REN (0.36) | RENKDM4EALDH1A1F2 | |
| SCHEMBL4972222 | 0.85 | REN (0.52) | RENCYP3A4 | |
| SCHEMBL4971315 | 0.83 | REN (0.49) | RENCYP3A4 | |
| SCHEMBL2329575 | 0.83 | REN (0.43) | RENCYP3A4ALDH1A1MEN1KMT2A | |
| SCHEMBL2329579 | 0.83 | REN (0.43) | RENCYP3A4ALDH1A1MEN1KMT2A | |
| SCHEMBL2329573 | 0.83 | REN (0.43) | RENCYP3A4ALDH1A1MEN1KMT2A | |
| SCHEMBL4971018 | 0.79 | REN (0.46) | RENKDM4EALDH1A1GAA | |
| SCHEMBL4972804 | 0.78 | REN (0.43) | RENCYP3A4 | |
| SCHEMBL4972809 | 0.78 | REN (0.43) | RENCYP3A4 | |
| SCHEMBL4971676 | 0.78 | REN (0.37) | RENKDM4EMC4R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2081927-A1 | PIPERIDINE DERIVATIVES AS RENIN INHIBITORS | Vitae Pharmaceuticals, Inc. (US) | 2009-07-29 | — | — | EP | disclosed |
| WO-2008036216-A1 | PIPERIDINE DERIVATIVES AS RENIN INHIBITORS | VITAE PHARMACEUTICALS, INC. (US) | 2008-03-27 | — | — | WO | disclosed |