Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 6/20 | 0.34 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
| ▸ | RAPGEF4 | Q8WZA2 | 2/20 | 0.33 |
| ▸ | PPME1 | Q9Y570 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.31 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.31 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3967149 | 0.92 | RAPGEF4 (0.42) | PTGDR2POLBRAPGEF4PPME1ALDH1A1 | |
| SCHEMBL3964356 | 0.91 | PTGDR2 (0.39) | HTR6PTGDR2RAPGEF4PPME1 | |
| SCHEMBL3973994 | 0.91 | PTGDR2 (0.40) | HTR6PTGDR2POLBRAPGEF4PPME1 | |
| SCHEMBL3968885 | 0.90 | PPME1 (0.37) | HTR6PTGDR2POLBRAPGEF4PPME1 | |
| SCHEMBL3967602 | 0.87 | RAPGEF4 (0.34) | HTR6PTGDR2POLBRAPGEF4PPME1 | |
| SCHEMBL3967733 | 0.87 | PTGDR2 (0.40) | PTGDR2RAPGEF4PPME1ALDH1A1 | |
| SCHEMBL3964361 | 0.86 | CYP3A4 (0.36) | PTGDR2HIF1ARAPGEF4MAPT | |
| SCHEMBL3967117 | 0.85 | POLB (0.36) | HTR6PTGDR2POLBHIF1ARAPGEF4 | |
| SCHEMBL3967784 | 0.84 | RAPGEF4 (0.35) | HTR6PTGDR2POLBRAPGEF4PPME1 | |
| SCHEMBL3970095 | 0.82 | RAPGEF4 (0.43) | HTR6PTGDR2RAPGEF4PPME1AKR1C3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009044147-A1 | INDOLIZINE DERIVATIVES WITH CRTH2 RECEPTOR AFFINITY FOR THE TREATMENT OF INFLAMMATORY DISEASES | ARGENTA DISCOVERY LIMITED (GB) | 2009-04-09 | — | — | WO | disclosed |