Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAPGEF4 | Q8WZA2 | 3/20 | 0.34 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.33 |
| ▸ | PPME1 | Q9Y570 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | HTR6 | P50406 | 4/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3968885 | 0.94 | PPME1 (0.37) | RAPGEF4PTGDR2PPME1POLBHTR6 | |
| SCHEMBL3967149 | 0.92 | RAPGEF4 (0.42) | RAPGEF4PTGDR2PPME1POLB | |
| SCHEMBL3973994 | 0.91 | PTGDR2 (0.40) | RAPGEF4PTGDR2PPME1POLBHTR6 | |
| SCHEMBL3967733 | 0.91 | PTGDR2 (0.40) | RAPGEF4PTGDR2PPME1 | |
| SCHEMBL3972665 | 0.91 | PTGDR2 (0.38) | RAPGEF4PTGDR2PPME1HTR6 | |
| SCHEMBL3967117 | 0.89 | POLB (0.36) | RAPGEF4PTGDR2PPME1POLBHTR6 | |
| SCHEMBL3967784 | 0.87 | RAPGEF4 (0.35) | RAPGEF4PTGDR2PPME1POLBHTR6 | |
| SCHEMBL3968063 | 0.87 | HTR6 (0.34) | RAPGEF4PTGDR2PPME1POLBHTR6 | |
| SCHEMBL3964361 | 0.85 | CYP3A4 (0.36) | RAPGEF4PTGDR2 | |
| SCHEMBL3968730 | 0.84 | PTGDR2 (0.42) | RAPGEF4PTGDR2PPME1HTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009044147-A1 | INDOLIZINE DERIVATIVES WITH CRTH2 RECEPTOR AFFINITY FOR THE TREATMENT OF INFLAMMATORY DISEASES | ARGENTA DISCOVERY LIMITED (GB) | 2009-04-09 | — | — | WO | disclosed |