Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 3/20 | 0.66 |
| ▸ | MTNR1B | P49286 | 3/20 | 0.66 |
| ▸ | PLA2G4A | P47712 | 8/20 | 0.54 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.53 |
| ▸ | HTR6 | P50406 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | NQO2 | P16083 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.45 |
| ▸ | FAAH | O00519 | 1/20 | 0.45 |
| ▸ | ACHE | P22303 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4207303 | 0.93 | MTNR1A (0.64) | MTNR1AMTNR1BPLA2G4APTPN1HTR6 | |
| SCHEMBL3970925 | 0.90 | MTNR1A (0.55) | MTNR1AMTNR1BPLA2G4APTPN1HTR6 | |
| SCHEMBL3972866 | 0.90 | MTNR1A (0.55) | MTNR1AMTNR1BPLA2G4APTPN1CYP2C19 | |
| SCHEMBL13883746 | 0.88 | MTNR1A (0.52) | MTNR1AMTNR1BPLA2G4APTPN1CYP1A2 | |
| SCHEMBL3970852 | 0.87 | MTNR1A (0.54) | MTNR1AMTNR1BPLA2G4A | |
| SCHEMBL13883771 | 0.85 | MTNR1A (0.56) | MTNR1AMTNR1BPLA2G4APTPN1HTR6 | |
| SCHEMBL3970351 | 0.76 | MTNR1A (0.51) | MTNR1AMTNR1BPLA2G4A | |
| SCHEMBL3974599 | 0.75 | PLA2G4A (0.54) | MTNR1AMTNR1BPLA2G4AL3MBTL1 | |
| SCHEMBL13884082 | 0.73 | MTNR1A (0.57) | MTNR1AMTNR1BPLA2G4AHTR6NQO2 | |
| SCHEMBL3969848 | 0.73 | PLA2G4A (0.52) | MTNR1AMTNR1BPLA2G4AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009047240-A1 | INDOLE DERIVATIVES USEFUL AS PPAR ACTIVATORS | SMITHKLINE BEECHAM CORPORATION (US) | 2009-04-16 | — | — | WO | claimed |
| WO-2009047240-A1 | INDOLE DERIVATIVES USEFUL AS PPAR ACTIVATORS | SMITHKLINE BEECHAM CORPORATION (US) | 2009-04-16 | — | — | WO | disclosed |