Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 1/20 | 0.54 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.54 |
| ▸ | PLA2G4A | P47712 | 8/20 | 0.53 |
| ▸ | METTL3 | Q86U44 | 2/20 | 0.41 |
| ▸ | METTL14 | Q9HCE5 | 2/20 | 0.41 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.41 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.41 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.41 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3969854 | 0.87 | MTNR1A (0.66) | MTNR1AMTNR1BPLA2G4A | |
| SCHEMBL3970925 | 0.86 | MTNR1A (0.55) | MTNR1AMTNR1BPLA2G4AMRGPRX4 | |
| SCHEMBL4207303 | 0.85 | MTNR1A (0.64) | MTNR1AMTNR1BPLA2G4A | |
| SCHEMBL3972866 | 0.85 | MTNR1A (0.55) | MTNR1AMTNR1BPLA2G4AALDH1A1 | |
| SCHEMBL13883771 | 0.80 | MTNR1A (0.56) | MTNR1AMTNR1BPLA2G4A | |
| SCHEMBL13883746 | 0.76 | MTNR1A (0.52) | MTNR1AMTNR1BPLA2G4AALDH1A1 | |
| SCHEMBL28650889 | 0.74 | PTPN1 (0.61) | GRIN1GRIN2BADAMTS5ALDH1A1 | |
| SCHEMBL3970351 | 0.74 | MTNR1A (0.51) | MTNR1AMTNR1BPLA2G4A | |
| SCHEMBL3974599 | 0.73 | PLA2G4A (0.54) | MTNR1AMTNR1BPLA2G4AALDH1A1 | |
| SCHEMBL3969848 | 0.72 | PLA2G4A (0.52) | MTNR1AMTNR1BPLA2G4AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009047240-A1 | INDOLE DERIVATIVES USEFUL AS PPAR ACTIVATORS | SMITHKLINE BEECHAM CORPORATION (US) | 2009-04-16 | — | — | WO | claimed |
| WO-2009047240-A1 | INDOLE DERIVATIVES USEFUL AS PPAR ACTIVATORS | SMITHKLINE BEECHAM CORPORATION (US) | 2009-04-16 | — | — | WO | disclosed |