Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 1/20 | 0.55 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.55 |
| ▸ | PLA2G4A | P47712 | 9/20 | 0.50 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.49 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 3/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | CASP3 | P42574 | 1/20 | 0.42 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.42 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3969854 | 0.90 | MTNR1A (0.66) | MTNR1AMTNR1BPLA2G4ACYP2C19PTPN1 | |
| SCHEMBL3970925 | 0.88 | MTNR1A (0.55) | MTNR1AMTNR1BPLA2G4APOLBGAA | |
| SCHEMBL4207303 | 0.85 | MTNR1A (0.64) | MTNR1AMTNR1BPLA2G4APOLBGAA | |
| SCHEMBL3970852 | 0.85 | MTNR1A (0.54) | MTNR1AMTNR1BPLA2G4AALDH1A1 | |
| SCHEMBL3971256 | 0.81 | NPC1 (0.47) | MTNR1AMTNR1BPLA2G4AALDH1A1POLB | |
| SCHEMBL13883771 | 0.81 | MTNR1A (0.56) | MTNR1AMTNR1BPLA2G4APOLBCYP2C19 | |
| SCHEMBL13883789 | 0.79 | MTNR1A (0.45) | MTNR1AMTNR1BPLA2G4ARAB9ANPC1 | |
| SCHEMBL13883746 | 0.79 | MTNR1A (0.52) | MTNR1AMTNR1BPLA2G4AALDH1A1CYP2C19 | |
| SCHEMBL3971114 | 0.79 | HIF1A (0.45) | MTNR1AMTNR1BPLA2G4AHIF1AEPAS1 | |
| SCHEMBL3976741 | 0.76 | MTNR1A (0.49) | MTNR1AMTNR1BPLA2G4AALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009047240-A1 | INDOLE DERIVATIVES USEFUL AS PPAR ACTIVATORS | SMITHKLINE BEECHAM CORPORATION (US) | 2009-04-16 | — | — | WO | disclosed |