Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 4/20 | 0.66 |
| ▸ | MMP13 | P45452 | 3/20 | 0.62 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.62 |
| ▸ | MMP12 | P39900 | 5/20 | 0.60 |
| ▸ | MMP3 | P08254 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL3969077 | 1.00 | MMP2 (0.66) | MMP2MMP13ADAM17MMP12MMP3 | |
| SCHEMBL3964572 | 0.95 | MMP2 (0.72) | MMP2MMP13ADAM17MMP12MMP3 | |
| SCHEMBL3968255 | 0.95 | MMP2 (0.72) | MMP2MMP13ADAM17MMP12MMP3 | |
| Trifluoroacetic Acid SCHEMBL3967595 | 0.86 | MMP2 (0.87) | MMP2MMP13ADAM17MMP12 | |
| Trifluoroacetic Acid SCHEMBL3968346 | 0.85 | MMP2 (0.91) | MMP2MMP13ADAM17MMP12 | |
| SCHEMBL3969900 | 0.81 | MMP2 (0.53) | MMP2MMP13ADAM17 | |
| SCHEMBL3969083 | 0.81 | MMP2 (0.53) | MMP2MMP13ADAM17 | |
| Trifluoroacetic Acid SCHEMBL6101844 | 0.81 | MMP13 (0.58) | MMP2MMP13ADAM17MMP12 | |
| Trifluoroacetic Acid SCHEMBL3974872 | 0.80 | MMP2 (0.65) | MMP2ADAM17MMP12MMP3 | |
| Trifluoroacetic Acid SCHEMBL3966506 | 0.80 | MMP2 (0.71) | MMP2ADAM17MMP12MMP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7595317-B2 | Barbituric acid derivatives as inhibitors of TNF-α converting enzyme (TACE) and/or matrix metalloproteinases | BRISTOL-MYERS SQUIBB COMPANY (US) | 2009-09-29 | — | — | US | disclosed |
| US-7294624-B2 | Osteoporosis; antiarthritic agents | BRISTOL MYERS SQUIBB COMPANY (US) | 2007-11-13 | — | — | US | disclosed |
| US-20070167451-A1 | BARBITURIC ACID DERIVATIVES AS INHIBITORS OF TNF-alpha CONVERTING ENZYME (TACE) AND/OR MATRIX METALLOPROTEINASES | DUAN JINGWU | 2007-07-19 | — | — | US | disclosed |
| US-20030229084-A1 | Barbituric acid derivatives as inhibitors of TNF-alpha converting enzyme (TACE) and/or matrix metalloproteinases | BRISTOL-MYERS SQUIBB COMPANY | 2003-12-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070167451-A1 | BARBITURIC ACID DERIVATIVES AS INHIBITORS OF TNF-alpha CONVERTING ENZYME (TACE) AND/OR MATRIX METALLOPROTEINASES | TNF, MMP9, MMP3 | MMP2 6/4885MMP13 8/4885ADAM17 27/4885 |
| US-20030229084-A1 | Barbituric acid derivatives as inhibitors of TNF-alpha converting enzyme (TACE) and/or matrix metalloproteinases | TNF, MMP3, TIMP3 | MMP2 8/4885MMP13 4/4885ADAM17 38/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.