Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PROKR1 | Q8TCW9 | 7/20 | 0.46 |
| ▸ | MGLL | Q99685 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | HSD11B1 | P28845 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1015893 | 0.86 | HTT (0.48) | PROKR1MGLLALDH1A1MAPTHPGD | |
| SCHEMBL13210964 | 0.80 | HTR2C (0.39) | PROKR1MGLLHSD11B1CHRM2CHRM1 | |
| SCHEMBL4562753 | 0.78 | ALDH1A1 (0.47) | ALDH1A1LMNARAB9AMAPTHPGD | |
| SCHEMBL1014709 | 0.72 | MTNR1A (0.47) | PROKR1ALDH1A1CHRM2CHRM1HPGD | |
| SCHEMBL1018430 | 0.72 | MMP1 (0.47) | PROKR1ALDH1A1CHRM2CHRM1HPGD | |
| SCHEMBL2636579 | 0.70 | HSD11B1 (0.61) | ALDH1A1LMNARAB9AHSD11B1MAPT | |
| SCHEMBL23326213 | 0.69 | PTGDR2 (0.57) | PROKR1ALDH1A1LMNAHSD11B1HPGD | |
| SCHEMBL3962210 | 0.69 | MEN1 (0.47) | RAB9AMAPTNPC1 | |
| SCHEMBL4777118 | 0.69 | GAA (0.49) | MGLLALDH1A1LMNARAB9AHSD11B1 | |
| SCHEMBL1014844 | 0.69 | STS (0.53) | ALDH1A1CHRM2CHRM1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2081890-A1 | ARYLSULFONYL PYRROLIDINES AS 5-HT6 INHIBITORS | F. Hoffmann-Roche AG (CH) | 2009-07-29 | — | — | EP | disclosed |
| WO-2008055847-A1 | ARYLSULFONYL PYRROLIDINES AS 5-HT6 INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2008-05-15 | — | — | WO | disclosed |