Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB1 | P08183 | 1/20 | 0.51 |
| ▸ | TNF | P01375 | 2/20 | 0.43 |
| ▸ | TNFSF11 | O14788 | 1/20 | 0.43 |
| ▸ | PLA2G4A | P47712 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | APEX1 | P27695 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 5/20 | 0.40 |
| ▸ | DRD3 | P35462 | 5/20 | 0.40 |
| ▸ | HTR1A | P08908 | 3/20 | 0.39 |
| ▸ | HTR2A | P28223 | 3/20 | 0.39 |
| ▸ | HTR7 | P34969 | 3/20 | 0.39 |
| ▸ | HRH1 | P35367 | 3/20 | 0.39 |
| ▸ | HTR2B | P41595 | 3/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3973169 | 0.85 | ABCB1 (0.51) | ABCB1PLA2G4AKDM4EALOX15APEX1 | |
| SCHEMBL13883895 | 0.78 | ABCB1 (0.53) | ABCB1PLA2G4ADRD2DRD3 | |
| SCHEMBL3972294 | 0.77 | NAMPT (0.48) | PLA2G4A | |
| SCHEMBL1356475 | 0.72 | TNF (0.51) | TNFTNFSF11PLA2G4AKMT2A | |
| SCHEMBL3971256 | 0.71 | NPC1 (0.47) | PLA2G4AKMT2A | |
| SCHEMBL31378117 | 0.71 | TEAD1 (0.55) | PLA2G4AKDM4E | |
| SCHEMBL14489662 | 0.70 | SIGMAR1 (0.56) | — | |
| SCHEMBL7962844 | 0.69 | ACACB (0.45) | ABCB1DRD2DRD3HTR1AHTR2A | |
| SCHEMBL13883789 | 0.69 | MTNR1A (0.45) | PLA2G4A | |
| SCHEMBL1357522 | 0.69 | TNF (0.48) | TNFTNFSF11PLA2G4AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009047240-A1 | INDOLE DERIVATIVES USEFUL AS PPAR ACTIVATORS | SMITHKLINE BEECHAM CORPORATION (US) | 2009-04-16 | — | — | WO | disclosed |