Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.45 |
| ▸ | RAB9A | P51151 | 6/20 | 0.44 |
| ▸ | NPC1 | O15118 | 5/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.41 |
| ▸ | RELA | Q04206 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | PLA2G4A | P47712 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3967394 | 0.85 | PLA2G4A (0.46) | SMN1; SMN2RAB9ANPC1MAPTMEN1 | |
| SCHEMBL3971169 | 0.83 | PLA2G4A (0.45) | MAPTTP53MEN1KMT2APLA2G4A | |
| SCHEMBL3972869 | 0.83 | CYSLTR2 (0.40) | NPC1USP2ALDH1A1PLA2G4A | |
| SCHEMBL3972961 | 0.82 | RAB9A (0.45) | SMN1; SMN2RAB9ANPC1MAPTMEN1 | |
| SCHEMBL3971114 | 0.82 | HIF1A (0.45) | SMN1; SMN2RAB9ANPC1MAPTPLA2G4A | |
| SCHEMBL3976087 | 0.81 | NPC1 (0.49) | SMN1; SMN2RAB9ANPC1MAPTNFKB1 | |
| SCHEMBL3974621 | 0.76 | MAPK8 (0.46) | SMN1; SMN2RAB9ANPC1MAPTHTT | |
| SCHEMBL13577923 | 0.75 | CPT2 (0.47) | SMN1; SMN2RAB9ANPC1MAPTATM | |
| SCHEMBL3972129 | 0.73 | PLA2G4A (0.53) | PLA2G4A | |
| SCHEMBL3970202 | 0.72 | RAB9A (0.47) | SMN1; SMN2RAB9ANPC1MAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009047240-A1 | INDOLE DERIVATIVES USEFUL AS PPAR ACTIVATORS | SMITHKLINE BEECHAM CORPORATION (US) | 2009-04-16 | — | — | WO | disclosed |