Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.49 |
| ▸ | RAB9A | P51151 | 3/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | RORC | P51449 | 2/20 | 0.43 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.41 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.41 |
| ▸ | PLA2G4A | P47712 | 10/20 | 0.41 |
| ▸ | METTL3 | Q86U44 | 2/20 | 0.39 |
| ▸ | METTL14 | Q9HCE5 | 2/20 | 0.39 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.39 |
| ▸ | MITF | O75030 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.39 |
| ▸ | RELA | Q04206 | 1/20 | 0.39 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.39 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3972961 | 0.91 | RAB9A (0.45) | NPC1RAB9ASMN1; SMN2KDM4EMAPT | |
| SCHEMBL3967394 | 0.85 | PLA2G4A (0.46) | NPC1RAB9ASMN1; SMN2KDM4EMAPT | |
| SCHEMBL3974621 | 0.84 | MAPK8 (0.46) | NPC1RAB9ASMN1; SMN2MAPTMTNR1A | |
| SCHEMBL3971169 | 0.83 | PLA2G4A (0.45) | MAPTRORCMTNR1AMTNR1BPLA2G4A | |
| SCHEMBL3971114 | 0.82 | HIF1A (0.45) | NPC1RAB9ASMN1; SMN2KDM4EMAPT | |
| SCHEMBL3972371 | 0.81 | SMN1; SMN2 (0.45) | NPC1RAB9ASMN1; SMN2MAPTPLA2G4A | |
| SCHEMBL3970202 | 0.80 | RAB9A (0.47) | NPC1RAB9ASMN1; SMN2KDM4EMAPT | |
| SCHEMBL3972869 | 0.78 | CYSLTR2 (0.40) | NPC1RORCMTNR1AMTNR1BPLA2G4A | |
| SCHEMBL3975570 | 0.77 | RAB9A (0.47) | RAB9AMAPTRORCMTNR1AMTNR1B | |
| SCHEMBL4340830 | 0.75 | NPC1 (0.48) | NPC1RAB9ASMN1; SMN2KDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009047240-A1 | INDOLE DERIVATIVES USEFUL AS PPAR ACTIVATORS | SMITHKLINE BEECHAM CORPORATION (US) | 2009-04-16 | — | — | WO | claimed |
| WO-2009047240-A1 | INDOLE DERIVATIVES USEFUL AS PPAR ACTIVATORS | SMITHKLINE BEECHAM CORPORATION (US) | 2009-04-16 | — | — | WO | disclosed |