Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 5/20 | 0.45 |
| ▸ | NPC1 | O15118 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | GFER | P55789 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.42 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.42 |
| ▸ | PLA2G4A | P47712 | 5/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | BRD4 | O60885 | 1/20 | 0.41 |
| ▸ | RORC | P51449 | 2/20 | 0.41 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.40 |
| ▸ | METTL3 | Q86U44 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3974621 | 0.93 | MAPK8 (0.46) | RAB9ANPC1SMN1; SMN2MAPTMEN1 | |
| SCHEMBL3976087 | 0.91 | NPC1 (0.49) | RAB9ANPC1SMN1; SMN2MAPTKDM4E | |
| SCHEMBL3967394 | 0.90 | PLA2G4A (0.46) | RAB9ANPC1SMN1; SMN2MAPTKDM4E | |
| SCHEMBL3971169 | 0.88 | PLA2G4A (0.45) | MAPTMEN1KMT2AMTNR1AMTNR1B | |
| SCHEMBL3970202 | 0.88 | RAB9A (0.47) | RAB9ANPC1SMN1; SMN2MAPTKDM4E | |
| SCHEMBL3971114 | 0.88 | HIF1A (0.45) | RAB9ANPC1SMN1; SMN2MAPTKDM4E | |
| SCHEMBL3975570 | 0.85 | RAB9A (0.47) | RAB9AMAPTMEN1GFERKMT2A | |
| SCHEMBL13883894 | 0.83 | LTA4H (0.44) | RAB9AMAPTKDM4EL3MBTL1MEN1 | |
| SCHEMBL3972869 | 0.83 | CYSLTR2 (0.40) | NPC1ALDH1A1MTNR1AMTNR1BPLA2G4A | |
| SCHEMBL3972371 | 0.82 | SMN1; SMN2 (0.45) | RAB9ANPC1SMN1; SMN2MAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009047240-A1 | INDOLE DERIVATIVES USEFUL AS PPAR ACTIVATORS | SMITHKLINE BEECHAM CORPORATION (US) | 2009-04-16 | — | — | WO | claimed |
| WO-2009047240-A1 | INDOLE DERIVATIVES USEFUL AS PPAR ACTIVATORS | SMITHKLINE BEECHAM CORPORATION (US) | 2009-04-16 | — | — | WO | disclosed |
| WO-2009047240-A1 | INDOLE DERIVATIVES USEFUL AS PPAR ACTIVATORS | SMITHKLINE BEECHAM CORPORATION (US) | 2009-04-16 | — | — | WO | disclosed |