Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 2/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.60 |
| ▸ | MEN1 | O00255 | 8/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.58 |
| ▸ | POLB | P06746 | 4/20 | 0.58 |
| ▸ | MAPT | P10636 | 3/20 | 0.58 |
| ▸ | DDX3X | O00571 | 1/20 | 0.58 |
| ▸ | HTT | P42858 | 1/20 | 0.58 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.57 |
| ▸ | NPC1 | O15118 | 1/20 | 0.54 |
| ▸ | BLM | P54132 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | RECQL | P46063 | 1/20 | 0.53 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30069319 | 0.92 | ALDH1A1 (0.69) | RAB9AALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL1969093 | 0.92 | ALDH1A1 (0.69) | RAB9AALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL13623020 | 0.83 | ALDH1A1 (0.74) | RAB9AALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL913804 | 0.83 | DDX3X (0.65) | RAB9AALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL27833966 | 0.82 | ALDH1A1 (0.64) | RAB9AALDH1A1SMN1; SMN2MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL1026974 | 0.82 | ALDH1A1 (0.72) | RAB9AALDH1A1SMN1; SMN2MEN1KMT2A | |
| 3-Nitroaniline SCHEMBL6920323 | 0.82 | ALDH1A1 (0.71) | ALDH1A1SMN1; SMN2MEN1KMT2APOLB | |
| SCHEMBL5141415 | 0.81 | MEN1 (0.75) | RAB9AALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL4262411 | 0.81 | HDAC1 (0.58) | RAB9AALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL4749088 | 0.81 | L3MBTL1 (0.71) | RAB9AALDH1A1SMN1; SMN2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1907385-A4 | COMPOUNDS | SMITHKLINE BEECHAM CORP (US) | 2009-05-06 | — | — | EP | disclosed |
| EP-1907385-A2 | COMPOUNDS | SmithKline Beecham Corporation (US) | 2008-04-09 | — | — | EP | disclosed |
| WO-2007018941-A2 | PYRIMIDYL-THIOPHENE DERIVATIVES | SMITHKLINE BEECHAM CORPORATION (US) | 2007-02-15 | — | — | WO | disclosed |