Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DDX3X | O00571 | 2/20 | 0.65 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.62 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.62 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.62 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.62 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.62 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.62 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.62 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.62 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.62 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.62 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.61 |
| ▸ | HTT | P42858 | 5/20 | 0.58 |
| ▸ | MITF | O75030 | 5/20 | 0.58 |
| ▸ | POLB | P06746 | 2/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.58 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.51 |
| ▸ | NPC1 | O15118 | 3/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6213588 | 0.88 | HPGD (0.56) | DDX3XHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL11802189 | 0.87 | ALDH1A1 (0.67) | ALDH1A1HTTMITFPOLBMAPK1 | |
| SCHEMBL11418046 | 0.86 | HDAC3 (0.68) | DDX3XHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL6560326 | 0.84 | DDX3X (0.67) | DDX3XHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL3646404 | 0.84 | DDX3X (0.67) | DDX3XHDAC3HDAC4HDAC1HDAC7 | |
| 3-Nitroaniline SCHEMBL3972851 | 0.83 | RAB9A (0.61) | DDX3XHDAC1ALDH1A1HTTPOLB | |
| SCHEMBL9427642 | 0.82 | DDX3X (0.65) | DDX3XHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL397243 | 0.82 | POLB (0.67) | DDX3XHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL7935572 | 0.82 | DDX3X (0.65) | DDX3XHDAC3HDAC4HDAC1HDAC7 | |
| Hydrochloric Acid SCHEMBL8392614 | 0.81 | POLB (0.65) | DDX3XHDAC3HDAC4HDAC1HDAC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8853230-B2 | Inhibitors of JAK | PORTOLA PHARMACEUTICALS, INC. (US) | 2014-10-07 | — | — | US | disclosed |
| CN-102159564-B | Arylsulfonamide compounds and their use as 5-HT6 ligands | SUVEN LIFE SCIENCES LTD | 2014-06-18 | — | — | CN | disclosed |
| US-20130137673-A1 | INHIBITORS OF JAK | PORTOLA PHARMACEUTICALS, INC. (US) | 2013-05-30 | — | — | US | disclosed |
| EP-2346847-B1 | ARYL SULFONAMIDE AMINE COMPOUNDS AND THEIR USE AS 5-HT6 LIGANDS | SUVEN LIFE SCIENCES LTD (IN) | 2013-05-15 | — | — | EP | disclosed |
| US-8404720-B2 | Aryl sulfonamide amine compounds and their use as 5-HT6 ligands | SUVEN LIFE SCIENCES LIMITED (IN) | 2013-03-26 | — | — | US | disclosed |
| US-8367689-B2 | Inhibitors of JAK | PORTOLA PHARMACEUTICALS, INC. (US) | 2013-02-05 | — | — | US | disclosed |
| US-20120129816-A1 | ARYL SULFONAMIDE AMINE COMPOUNDS AND THEIR USE AS 5-HT6 LIGANDS | SUVEN LIFE SCIENCES LIMITED (IN) | 2012-05-24 | — | — | US | disclosed |
| CN-102159564-A | Arylsulfonamide compounds and their use as 5-HT6 ligands | SUVEN LIFE SCIENCES LTD | 2011-08-17 | — | — | CN | disclosed |
| EP-2346847-A1 | ARYL SULFONAMIDE AMINE COMPOUNDS AND THEIR USE AS 5-HT6 LIGANDS | Suven Life Sciences Limited (IN) | 2011-07-27 | — | — | EP | disclosed |
| US-20110005947-A1 | INHIBITORS OF JAK | PORTOLA PHARMACEUTICALS, INC. (US) | 2011-01-13 | — | — | US | disclosed |
| WO-2010129802-A1 | INHIBITORS OF JAK | PORTOLA PHARMACEUTICALS, INC. (US) | 2010-11-11 | — | — | WO | disclosed |
| WO-2010032258-A1 | ARYL SULFONAMIDE AMINE COMPOUNDS AND THEIR USE AS 5-HT6 LIGANDS | SUVEN LIFE SCIENCES LIMITED (IN) | 2010-03-25 | — | — | WO | disclosed |
| EP-0352222-B1 | Fibre-reactive formazane dyes, process for their preparation and their use | CIBA GEIGY AG (CH) | 1994-05-25 | — | — | EP | disclosed |
| US-5114430-A | Colorfast dyes that react with fibers to form red, orange or red color | CIBA-GEIGY CORPORATION (US) | 1992-05-19 | — | — | US | disclosed |
| US-4994562-A | Colorfast; for dyeing wool, silk | CIBA-GEIGY CORPORATION (US) | 1991-02-19 | — | — | US | disclosed |
| EP-0352222-A2 | Fibre-reactive formazane dyes, process for their preparation and their use | CIBA-GEIGY AG (CH) | 1990-01-24 | — | — | EP | disclosed |
| US-4220586-A | FASTNESS TO LIGHT, OVER-LACQUERING, MIGRATION, WEATHERING, AND HEAT | CIBA-GEIGY CORPORATION (US) | 1980-09-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130137673-A1 | INHIBITORS OF JAK | JAK1, JAK2, JAK3 | DDX3X 4709/4885HDAC3 1998/4885HDAC4 2504/4885 |
| US-20120129816-A1 | ARYL SULFONAMIDE AMINE COMPOUNDS AND THEIR USE AS 5-HT6 LIGANDS | HTR6, HTR1A, HTR5A | DDX3X 4322/4885HDAC3 1513/4885HDAC4 1037/4885 |
| US-20110005947-A1 | INHIBITORS OF JAK | JAK1, JAK2, JAK3 | DDX3X 4709/4885HDAC3 1998/4885HDAC4 2504/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.