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Eprosartan

Eprosartan

SCHEMBL3972893

CCCCc1ncc(/C=C(\Cc2cccs2)C(=O)O)n1Cc1ccc(C(=O)O)cc1.CCCCc1ncc(/C=C(\Cc2cccs2)C(=O)O)n1Cc1ccc(C(=O)O)cc1.CS(=O)(=O)O

nearest known ligand 0.92

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

AGTR1

The experimentally established mechanism targets of Eprosartan. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
▸ AGTR1 known ✓ P30556 2/20 0.92
▸ ABCC3 O15438 1/20 0.92
▸ ABCC2 Q92887 1/20 0.92

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Eprosartan SCHEMBL5785067 1.00 AGTR1 (0.92) AGTR1ABCC3ABCC2
Eprosartan SCHEMBL41397 1.00 AGTR1 (0.92) AGTR1ABCC3ABCC2
Eprosartan SCHEMBL41396 1.00 AGTR1 (0.92) AGTR1ABCC3ABCC2
Eprosartan SCHEMBL1504815 0.99 AGTR1 (0.91) AGTR1ABCC3ABCC2
Eprosartan SCHEMBL4382102 0.99 AGTR1 (0.91) AGTR1ABCC3ABCC2
Eprosartan SCHEMBL1504814 0.99 AGTR1 (0.91) AGTR1ABCC3ABCC2
Eprosartan SCHEMBL4382107 0.99 AGTR1 (0.91) AGTR1ABCC3ABCC2
Eprosartan SCHEMBL74813 0.97 AGTR1 (0.92) AGTR1ABCC3ABCC2
Eprosartan SCHEMBL156290 0.96 AGTR1 (1.00) AGTR1ABCC3ABCC2
Eprosartan SCHEMBL1815060 0.96 AGTR1 (1.00) AGTR1ABCC3ABCC2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1799263-A4 REDUCING ER STRESS IN THE TREATMENT OF OBESITY AND DIABETES HARVARD COLLEGE (US) 2009-07-29 — — EP disclosed
EP-1799263-A2 REDUCING ER STRESS IN THE TREATMENT OF OBESITY AND DIABETES The President and Fellows of Harvard College (US) 2007-06-27 — — EP disclosed
WO-2006031931-A2 REDUCING ER STRESS IN THE TREATMENT OF OBESITY AND DIABETES THE PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) 2006-03-23 — — WO disclosed