Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Eprosartan. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR1 known ✓ | P30556 | 2/20 | 0.92 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.92 |
| ▸ | ABCC2 | Q92887 | 1/20 | 0.92 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Eprosartan SCHEMBL41397 | 0.97 | AGTR1 (0.92) | AGTR1ABCC3ABCC2 | |
| Eprosartan SCHEMBL3972893 | 0.97 | AGTR1 (0.92) | AGTR1ABCC3ABCC2 | |
| Eprosartan SCHEMBL5785067 | 0.97 | AGTR1 (0.92) | AGTR1ABCC3ABCC2 | |
| Eprosartan SCHEMBL41396 | 0.97 | AGTR1 (0.92) | AGTR1ABCC3ABCC2 | |
| Eprosartan SCHEMBL6747993 | 0.97 | AGTR1 (0.98) | AGTR1ABCC3ABCC2 | |
| Eprosartan SCHEMBL6747994 | 0.97 | AGTR1 (0.98) | AGTR1ABCC3ABCC2 | |
| Eprosartan SCHEMBL1504814 | 0.96 | AGTR1 (0.91) | AGTR1ABCC3ABCC2 | |
| Eprosartan SCHEMBL1504815 | 0.96 | AGTR1 (0.91) | AGTR1ABCC3ABCC2 | |
| Eprosartan SCHEMBL4382102 | 0.96 | AGTR1 (0.91) | AGTR1ABCC3ABCC2 | |
| Eprosartan SCHEMBL4382107 | 0.96 | AGTR1 (0.91) | AGTR1ABCC3ABCC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8128909-B2 | Preparation of sterile aqueous suspensions comprising micronised crystalline active ingredients for inhalation | CHIESI FARMACEUTICI S.P.A. (IT) | 2012-03-06 | — | — | US | disclosed |
| EP-1572153-B1 | PREPARATION OF STERILE AQUEOUS SUSPENSIONS COMPRISING MICRONISED CRYSTALLINE ACTIVE INGREDIENTS FOR INHALATION | CHIESI FARMA SPA (IT) | 2012-02-08 | — | — | EP | disclosed |
| US-20070140980-A1 | Preparation of sterile aqueous suspensions comprising micronised crystalline active ingredients for inhalation | CHIESI FARMACEUTICI S.P.A. (IT) | 2007-06-21 | — | — | US | disclosed |
| EP-1572153-A1 | PREPARATION OF STERILE AQUEOUS SUSPENSIONS COMPRISING MICRONISED CRYSTALLINE ACTIVE INGREDIENTS FOR INHALATION | CHIESI FARMACEUTICI S.p.A. (IT) | 2005-09-14 | — | — | EP | disclosed |
| WO-2004054545-A1 | PREPARATION OF STERILE AQUEOUS SUSPENSIONS COMPRISING MICRONISED CRYSTALLINE ACTIVE INGREDIENTS FOR INHALATION | CHIESI FARMACEUTICI S.P.A. (IT) | 2004-07-01 | — | — | WO | disclosed |