Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 10/20 | 0.42 |
| ▸ | HCAR3 | P49019 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | PPARG | P37231 | 1/20 | 0.40 |
| ▸ | RXRB | P28702 | 1/20 | 0.39 |
| ▸ | TACR1 | P25103 | 3/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3977915 | 0.91 | PARP10 (0.39) | TACR1SLC6A2SLC6A4SLC6A3KCNH2 | |
| SCHEMBL4259000 | 0.88 | GCK (0.44) | RXRA | |
| SCHEMBL3978560 | 0.87 | RXRA (0.42) | RXRAHCAR3MAPTPPARG | |
| SCHEMBL3972951 | 0.87 | RXRA (0.42) | RXRAHCAR3MAPTPPARGTACR1 | |
| SCHEMBL3973372 | 0.85 | RXRA (0.41) | RXRAHCAR3MAPTPPARGSLC6A2 | |
| SCHEMBL3973033 | 0.85 | SSTR5 (0.42) | RXRAHCAR3MAPTPPARGRXRB | |
| SCHEMBL3979779 | 0.84 | RXRA (0.41) | RXRAHCAR3MAPTPPARGTACR1 | |
| SCHEMBL3977983 | 0.84 | SSTR5 (0.41) | RXRAHCAR3MAPTPPARGTACR1 | |
| SCHEMBL3973856 | 0.84 | L3MBTL1 (0.47) | RXRAMAPTPPARGSMN1; SMN2 | |
| SCHEMBL3978579 | 0.82 | SLC6A2 (0.41) | SLC6A2SLC6A4SLC6A3KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2054385-A2 | PHENYL, PYRIDINE AND QUINOLINE DERIVATIVES | F. Hoffmann-Roche AG (CH) | 2009-05-06 | — | — | EP | claimed |
| WO-2008019967-A2 | PHENYL, PYRIDINE AND QUINOLINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2008-02-21 | — | — | WO | claimed |
| EP-2054385-A2 | PHENYL, PYRIDINE AND QUINOLINE DERIVATIVES | F. Hoffmann-Roche AG (CH) | 2009-05-06 | — | — | EP | disclosed |
| WO-2008019967-A2 | PHENYL, PYRIDINE AND QUINOLINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2008-02-21 | — | — | WO | disclosed |