Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | REN | P00797 | 3/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | RXRA | P19793 | 5/20 | 0.41 |
| ▸ | PPARG | P37231 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | TAS2R14 | Q9NYV8 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | MBTPS1 | Q14703 | 3/20 | 0.38 |
| ▸ | F10 | P00742 | 1/20 | 0.38 |
| ▸ | PLAU | P00749 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3972925 | 0.93 | MAPK1 (0.44) | L3MBTL1RENALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL3973369 | 0.92 | REN (0.43) | L3MBTL1RENALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL3974286 | 0.91 | REN (0.43) | L3MBTL1RENALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL3973033 | 0.90 | SSTR5 (0.42) | RXRAPPARGMAPT | |
| SCHEMBL3973372 | 0.90 | RXRA (0.41) | RXRAPPARGALDH1A1MAPT | |
| SCHEMBL3979779 | 0.89 | RXRA (0.41) | RXRAPPARGMAPT | |
| SCHEMBL3977983 | 0.89 | SSTR5 (0.41) | RXRAPPARGMAPTMBTPS1 | |
| SCHEMBL3978560 | 0.87 | RXRA (0.42) | RXRAPPARGMAPT | |
| SCHEMBL3972951 | 0.87 | RXRA (0.42) | RXRAPPARGMAPT | |
| SCHEMBL3973371 | 0.87 | L3MBTL1 (0.53) | L3MBTL1RENTSHRALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2054385-A2 | PHENYL, PYRIDINE AND QUINOLINE DERIVATIVES | F. Hoffmann-Roche AG (CH) | 2009-05-06 | — | — | EP | claimed |
| WO-2008019967-A2 | PHENYL, PYRIDINE AND QUINOLINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2008-02-21 | — | — | WO | claimed |
| EP-2054385-A2 | PHENYL, PYRIDINE AND QUINOLINE DERIVATIVES | F. Hoffmann-Roche AG (CH) | 2009-05-06 | — | — | EP | disclosed |
| WO-2008019967-A2 | PHENYL, PYRIDINE AND QUINOLINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2008-02-21 | — | — | WO | disclosed |