Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCK | P35557 | 16/20 | 0.44 |
| ▸ | RARA | P10276 | 1/20 | 0.44 |
| ▸ | RARB | P10826 | 1/20 | 0.44 |
| ▸ | RARG | P13631 | 1/20 | 0.44 |
| ▸ | RXRA | P19793 | 2/20 | 0.41 |
| ▸ | MBTPS1 | Q14703 | 1/20 | 0.41 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.40 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3974019 | 0.91 | MBTPS1 (0.40) | GCKRARARARBRARGMBTPS1 | |
| SCHEMBL3973405 | 0.88 | RXRA (0.42) | RXRA | |
| SCHEMBL3973401 | 0.82 | SLC6A2 (0.43) | — | |
| SCHEMBL3978560 | 0.80 | RXRA (0.42) | RXRA | |
| SCHEMBL3972951 | 0.80 | RXRA (0.42) | RXRA | |
| SCHEMBL3974287 | 0.80 | IRAK4 (0.42) | MBTPS1SLC6A9SLC6A5 | |
| SCHEMBL4209767 | 0.80 | SLC6A9 (0.38) | GCKMBTPS1SLC6A9SLC6A5 | |
| SCHEMBL3977915 | 0.80 | PARP10 (0.39) | — | |
| SCHEMBL4594515 | 0.78 | NPC1 (0.39) | GCKMBTPS1SLC6A9SLC6A5 | |
| SCHEMBL4594412 | 0.78 | HDAC6 (0.38) | GCKMBTPS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2054385-A2 | PHENYL, PYRIDINE AND QUINOLINE DERIVATIVES | F. Hoffmann-Roche AG (CH) | 2009-05-06 | — | — | EP | claimed |
| WO-2008019967-A2 | PHENYL, PYRIDINE AND QUINOLINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2008-02-21 | — | — | WO | claimed |
| EP-2054385-A2 | PHENYL, PYRIDINE AND QUINOLINE DERIVATIVES | F. Hoffmann-Roche AG (CH) | 2009-05-06 | — | — | EP | disclosed |
| WO-2008019967-A2 | PHENYL, PYRIDINE AND QUINOLINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2008-02-21 | — | — | WO | disclosed |