Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 8/20 | 0.52 |
| ▸ | SLC6A4 | P31645 | 8/20 | 0.52 |
| ▸ | SLC6A3 | Q01959 | 6/20 | 0.52 |
| ▸ | REN | P00797 | 2/20 | 0.41 |
| ▸ | CYP19A1 | P11511 | 4/20 | 0.41 |
| ▸ | NOS2 | P35228 | 1/20 | 0.40 |
| ▸ | KDM1A | O60341 | 3/20 | 0.40 |
| ▸ | STS | P08842 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.39 |
| ▸ | PDE4A | P27815 | 1/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.38 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4544203 | 0.89 | SLC6A2 (0.45) | SLC6A2SLC6A4SLC6A3REN | |
| SCHEMBL3971153 | 0.88 | SLC6A4 (0.52) | SLC6A2SLC6A4SLC6A3CYP19A1NOS2 | |
| SCHEMBL3973911 | 0.86 | SLC6A2 (0.40) | SLC6A2SLC6A4SLC6A3RENCYP19A1 | |
| SCHEMBL3973371 | 0.84 | L3MBTL1 (0.53) | SLC6A2SLC6A4SLC6A3REN | |
| SCHEMBL3971352 | 0.82 | REN (0.41) | SLC6A2SLC6A4SLC6A3RENKDM1A | |
| SCHEMBL4705848 | 0.79 | SLC6A2 (0.41) | SLC6A2SLC6A4SLC6A3RENNOS2 | |
| SCHEMBL3998910 | 0.78 | REN (0.43) | SLC6A2SLC6A4SLC6A3RENKCNH2 | |
| SCHEMBL3931492 | 0.77 | REN (0.41) | SLC6A2SLC6A4SLC6A3RENKCNH2 | |
| SCHEMBL3972421 | 0.76 | SLC6A2 (0.41) | SLC6A2SLC6A4SLC6A3KDM1A | |
| SCHEMBL3974409 | 0.76 | GAA (0.53) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2054385-A2 | PHENYL, PYRIDINE AND QUINOLINE DERIVATIVES | F. Hoffmann-Roche AG (CH) | 2009-05-06 | — | — | EP | claimed |
| WO-2008019967-A2 | PHENYL, PYRIDINE AND QUINOLINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2008-02-21 | — | — | WO | claimed |
| EP-2054385-A2 | PHENYL, PYRIDINE AND QUINOLINE DERIVATIVES | F. Hoffmann-Roche AG (CH) | 2009-05-06 | — | — | EP | disclosed |
| WO-2008019967-A2 | PHENYL, PYRIDINE AND QUINOLINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2008-02-21 | — | — | WO | disclosed |