Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 12/20 | 0.45 |
| ▸ | SLC6A4 | P31645 | 12/20 | 0.45 |
| ▸ | SLC6A3 | Q01959 | 11/20 | 0.45 |
| ▸ | REN | P00797 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3973450 | 0.89 | SLC6A2 (0.52) | SLC6A2SLC6A4SLC6A3REN | |
| SCHEMBL3973371 | 0.88 | L3MBTL1 (0.53) | SLC6A2SLC6A4SLC6A3RENKMT2A | |
| SCHEMBL3971352 | 0.85 | REN (0.41) | SLC6A2SLC6A4SLC6A3RENKMT2A | |
| SCHEMBL3998910 | 0.81 | REN (0.43) | SLC6A2SLC6A4SLC6A3RENKMT2A | |
| SCHEMBL3974409 | 0.79 | GAA (0.53) | KMT2ANPSR1MEN1MAPTKDM4E | |
| SCHEMBL3931492 | 0.78 | REN (0.41) | SLC6A2SLC6A4SLC6A3RENMAPT | |
| SCHEMBL3973911 | 0.78 | SLC6A2 (0.40) | SLC6A2SLC6A4SLC6A3REN | |
| SCHEMBL4551382 | 0.78 | KDM4E (0.42) | SLC6A2SLC6A4SLC6A3RENNPSR1 | |
| SCHEMBL3973369 | 0.78 | REN (0.43) | SLC6A2SLC6A4SLC6A3RENNPSR1 | |
| SCHEMBL4551389 | 0.78 | MC4R (0.46) | SLC6A2SLC6A4SLC6A3RENKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2054385-A2 | PHENYL, PYRIDINE AND QUINOLINE DERIVATIVES | F. Hoffmann-Roche AG (CH) | 2009-05-06 | — | — | EP | disclosed |
| WO-2008019967-A2 | PHENYL, PYRIDINE AND QUINOLINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2008-02-21 | — | — | WO | disclosed |