Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 3/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | KDM1A | O60341 | 1/20 | 0.40 |
| ▸ | MAOA | P21397 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.39 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | SSTR5 | P35346 | 1/20 | 0.37 |
| ▸ | HRH1 | P35367 | 1/20 | 0.37 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.37 |
| ▸ | PDE4A | P27815 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4544203 | 0.85 | SLC6A2 (0.45) | RENSLC6A2SLC6A4SLC6A3ALDH1A1 | |
| SCHEMBL3973371 | 0.82 | L3MBTL1 (0.53) | RENSLC6A2SLC6A4SLC6A3ALDH1A1 | |
| SCHEMBL3973450 | 0.82 | SLC6A2 (0.52) | RENSLC6A2SLC6A4SLC6A3KDM1A | |
| SCHEMBL3974409 | 0.81 | GAA (0.53) | ALDH1A1MAPTKDM4EKMT2AMAPK1 | |
| SCHEMBL3998910 | 0.78 | REN (0.43) | RENSLC6A2SLC6A4SLC6A3ALDH1A1 | |
| SCHEMBL3973369 | 0.73 | REN (0.43) | RENSLC6A2SLC6A4SLC6A3ALDH1A1 | |
| SCHEMBL3979346 | 0.73 | REN (0.43) | RENSLC6A2SLC6A4SLC6A3ALDH1A1 | |
| SCHEMBL3972925 | 0.72 | MAPK1 (0.44) | RENSLC6A2SLC6A4SLC6A3ALDH1A1 | |
| SCHEMBL3973856 | 0.72 | L3MBTL1 (0.47) | RENALDH1A1MAPTKMT2ANPSR1 | |
| SCHEMBL3971319 | 0.71 | REN (0.42) | RENSLC6A2SLC6A4SLC6A3ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2054385-A2 | PHENYL, PYRIDINE AND QUINOLINE DERIVATIVES | F. Hoffmann-Roche AG (CH) | 2009-05-06 | — | — | EP | disclosed |
| WO-2008019967-A2 | PHENYL, PYRIDINE AND QUINOLINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2008-02-21 | — | — | WO | disclosed |