Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7580225 | 0.86 | ALOX15 (0.62) | KEAP1SMN1; SMN2ACE2ALOX15SIGMAR1 | |
| SCHEMBL4104385 | 0.83 | SIGMAR1 (0.38) | KEAP1SMN1; SMN2ACE2ALOX15SIGMAR1 | |
| SCHEMBL23775526 | 0.83 | KEAP1 (0.48) | KEAP1SMN1; SMN2ACE2ALOX15SIGMAR1 | |
| SCHEMBL101501 | 0.81 | KEAP1 (0.67) | KEAP1SMN1; SMN2ACE2ALOX15SIGMAR1 | |
| SCHEMBL1616800 | 0.81 | — | — | |
| SCHEMBL17404736 | 0.78 | GNAI3 (0.44) | SIGMAR1 | |
| SCHEMBL7609534 | 0.78 | ACE2 (0.31) | ACE2 | |
| SCHEMBL6248521 | 0.78 | KEAP1 (0.48) | KEAP1SMN1; SMN2ACE2ALOX15SIGMAR1 | |
| SCHEMBL5149279 | 0.78 | ALOX15 (0.50) | KEAP1SMN1; SMN2ACE2ALOX15SIGMAR1 | |
| SCHEMBL18712607 | 0.78 | ACE2 (0.31) | ACE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2054392-A2 | 2-ANILINO-4-(HETEROCYCLIC)AMINO-PYRIMIDINES AS INHIBITORS OF PROTEIN KINASE C-ALPHA | Boehringer Ingelheim International GmbH (DE) | 2009-05-06 | — | — | EP | disclosed |
| EP-1991528-A2 | MODULATORS OF ALPHA7 NICOTINIC ACETYLCHOLINE RECEPTORS AND THERAPEUTIC USES THEREOF | Siena Biotech S.p.A. (IT) | 2008-11-19 | — | — | EP | disclosed |
| WO-2007146981-A2 | 2-ANILINO-4-(HETEROCYCLIC)AMINO-PYRIMIDINES AS INHIBITORS OF PROTEIN KINASE C-ALPHA | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2007-12-21 | — | — | WO | disclosed |
| WO-2007098826-A2 | MODULATORS OF ALPHA7 NICOTINIC ACETYLCHOLINE RECEPTORS AND THERAPEUTIC USES THEREOF | SIENA BIOTECH S.P.A. (IT) | 2007-09-07 | — | — | WO | disclosed |