Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH2 | P25021 | 1/20 | 0.44 |
| ▸ | HRH1 | P35367 | 1/20 | 0.44 |
| ▸ | MMP2 | P08253 | 6/20 | 0.43 |
| ▸ | MMP3 | P08254 | 2/20 | 0.43 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.39 |
| ▸ | PGR | P06401 | 1/20 | 0.38 |
| ▸ | MCHR1 | Q99705 | 3/20 | 0.37 |
| ▸ | BACE1 | P56817 | 1/20 | 0.37 |
| ▸ | XDH | P47989 | 1/20 | 0.36 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.36 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.36 |
| ▸ | MMP12 | P39900 | 1/20 | 0.36 |
| ▸ | MMP13 | P45452 | 1/20 | 0.36 |
| ▸ | SGK1 | O00141 | 1/20 | 0.36 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.36 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3338423 | 0.79 | HRH2 (0.46) | HRH2HRH1MMP2MMP3PGR | |
| SCHEMBL1786987 | 0.79 | ALDH1A1 (0.42) | — | |
| SCHEMBL1785222 | 0.76 | HRH2 (0.43) | HRH2HRH1MMP2MMP3PGR | |
| SCHEMBL3772254 | 0.66 | EGLN1 (0.39) | HRH2HRH1SLC22A12EGLN1SGK1 | |
| SCHEMBL7047932 | 0.65 | HRH2 (0.64) | HRH2HRH1MMP2MMP3 | |
| SCHEMBL7044802 | 0.65 | MMP3 (0.70) | HRH2HRH1MMP2MMP3MMP13 | |
| SCHEMBL19608731 | 0.64 | LMNA (0.60) | HRH2HRH1MMP2MMP3PGR | |
| SCHEMBL6410828 | 0.64 | HRH2 (0.62) | HRH2HRH1MMP2MMP3 | |
| SCHEMBL7928937 | 0.63 | MMP12 (0.54) | HRH2HRH1MMP2MMP3MMP12 | |
| SCHEMBL3660898 | 0.62 | MMP12 (0.51) | PGRMCHR1XDHSLC22A12MMP12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2054383-A2 | NOVEL COMPOUNDS AS ANTAGONISTS OR INVERSE AGONISTS AT OPIOID RECEPTORS | SmithKline Beecham Corporation (US) | 2009-05-06 | — | — | EP | disclosed |
| WO-2008021849-A2 | NOVEL COMPOUNDS AS ANTAGONISTS OR INVERSE AGONISTS AT OPIOID RECEPTORS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-02-21 | — | — | WO | disclosed |