Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MT-CO2 | P00403 | 1/20 | 0.38 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | CNR1 | P21554 | 3/20 | 0.34 |
| ▸ | STS | P08842 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3977769 | 0.82 | MT-CO2 (0.38) | MT-CO2MEN1KMT2AGAAHPGD | |
| SCHEMBL3969771 | 0.80 | MT-CO2 (0.38) | MT-CO2MEN1KMT2AGAAHPGD | |
| SCHEMBL3973790 | 0.76 | C5AR1 (0.40) | MT-CO2MEN1KMT2AGAACYP3A4 | |
| SCHEMBL3977773 | 0.75 | AOC3 (0.43) | MT-CO2MEN1KMT2AGAASMN1; SMN2 | |
| SCHEMBL3972679 | 0.74 | MT-CO2 (0.34) | MT-CO2MEN1KMT2AGAAALDH1A1 | |
| SCHEMBL9884410 | 0.73 | ALOX5 (0.42) | SMN1; SMN2ALDH1A1NPC1MAPTMAPK1 | |
| SCHEMBL22327650 | 0.71 | MT-CO2 (0.42) | MT-CO2MEN1KMT2AL3MBTL1CYP3A4 | |
| SCHEMBL12526565 | 0.71 | REN (0.35) | KMT2AALDH1A1NPC1MAPTMAPK1 | |
| SCHEMBL23564597 | 0.71 | POLB (0.40) | MT-CO2MEN1KMT2ACYP2C9CYP2C19 | |
| SCHEMBL22308423 | 0.71 | POLB (0.40) | MT-CO2MEN1KMT2ACYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2054418-A1 | DIHYDROTHIENO PYRIMIDINES AS AKT PROTEIN KINASE INHIBITORS | Array Biopharma, Inc. (US) | 2009-05-06 | — | — | EP | disclosed |
| WO-2008006039-A1 | DIHYDROTHIENO PYRIMIDINES AS AKT PROTEIN KINASE INHIBITORS | ARRAY BIOPHARMA INC. (US) | 2008-01-10 | — | — | WO | disclosed |