Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRD1 | P41143 | 3/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | GFER | P55789 | 1/20 | 0.38 |
| ▸ | PLEC | Q15149 | 1/20 | 0.38 |
| ▸ | HCAR3 | P49019 | 2/20 | 0.37 |
| ▸ | EZH2 | Q15910 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | IDO1 | P14902 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | NEU3 | Q9UQ49 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2433377 | 0.82 | ALDH1A1 (0.45) | OPRD1OPRM1KDM4EGAAALDH1A1 | |
| SCHEMBL3980320 | 0.81 | IDO1 (0.37) | EZH2JAK2IDO1 | |
| SCHEMBL3974267 | 0.71 | DRD3 (0.33) | ALDH1A1IDO1DRD3 | |
| SCHEMBL8158109 | 0.70 | ALDH1A1 (0.47) | KDM4EGAAALDH1A1MAPTTHRB | |
| SCHEMBL25433193 | 0.68 | KDM4E (0.39) | NPSR1KDM4EGAAALDH1A1MAPT | |
| SCHEMBL25433189 | 0.68 | KDM4E (0.39) | NPSR1KDM4EGAAALDH1A1MAPT | |
| SCHEMBL5929406 | 0.68 | NOS3 (0.40) | OPRD1OPRM1HCAR3OPRK1 | |
| SCHEMBL4088178 | 0.68 | HCAR3 (0.36) | NPSR1KDM4EGAAALDH1A1MAPT | |
| SCHEMBL1757694 | 0.67 | GRM1 (0.53) | KDM4EGAAALDH1A1MAPTKMT2A | |
| SCHEMBL2426837 | 0.67 | PPM1D (0.41) | KDM4EGAAALDH1A1KMT2ANEU3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2074120-A1 | TROPANE COMPOUNDS | Exelixis, Inc. (US) | 2009-07-01 | — | — | EP | disclosed |
| WO-2009055077-A1 | TROPANE COMPOUNDS | EXELIXIS, INC. (US) | 2009-04-30 | — | — | WO | disclosed |