Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MBTPS1 | Q14703 | 3/20 | 0.40 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.39 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 2/20 | 0.39 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.38 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.37 |
| ▸ | GCK | P35557 | 6/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.36 |
| ▸ | RARA | P10276 | 1/20 | 0.36 |
| ▸ | RARB | P10826 | 1/20 | 0.36 |
| ▸ | RARG | P13631 | 1/20 | 0.36 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4259000 | 0.91 | GCK (0.44) | MBTPS1SLC6A9SLC6A5GCKRARA | |
| SCHEMBL3977915 | 0.89 | PARP10 (0.39) | PARP10SLC6A2SLC6A4SLC6A3CHEK2 | |
| SCHEMBL3974287 | 0.87 | IRAK4 (0.42) | MBTPS1SLC6A9SLC6A5HTR2AIRAK4 | |
| SCHEMBL3973401 | 0.82 | SLC6A2 (0.43) | SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL3971524 | 0.81 | MAPK1 (0.36) | SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL3977954 | 0.80 | TACR1 (0.37) | MBTPS1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL3973958 | 0.80 | SSTR5 (0.40) | HTR2ASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL3978538 | 0.80 | REN (0.43) | HTR2ASLC6A2SLC6A4 | |
| SCHEMBL3973405 | 0.80 | RXRA (0.42) | SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL4209767 | 0.79 | SLC6A9 (0.38) | MBTPS1SLC6A9SLC6A5HTR2AGCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2054385-A2 | PHENYL, PYRIDINE AND QUINOLINE DERIVATIVES | F. Hoffmann-Roche AG (CH) | 2009-05-06 | — | — | EP | claimed |
| WO-2008019967-A2 | PHENYL, PYRIDINE AND QUINOLINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2008-02-21 | — | — | WO | claimed |
| EP-2054385-A2 | PHENYL, PYRIDINE AND QUINOLINE DERIVATIVES | F. Hoffmann-Roche AG (CH) | 2009-05-06 | — | — | EP | disclosed |
| WO-2008019967-A2 | PHENYL, PYRIDINE AND QUINOLINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2008-02-21 | — | — | WO | disclosed |