Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.57 |
| ▸ | MEN1 | O00255 | 2/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.57 |
| ▸ | MAPT | P10636 | 2/20 | 0.57 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.57 |
| ▸ | MITF | O75030 | 1/20 | 0.57 |
| ▸ | RAB9A | P51151 | 1/20 | 0.57 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.56 |
| ▸ | CPT1A | P50416 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.47 |
| ▸ | IMPDH1 | P20839 | 1/20 | 0.47 |
| ▸ | TUBB1 | Q9H4B7 | 2/20 | 0.47 |
| ▸ | HTR4 | Q13639 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27908679 | 0.81 | NR4A2 (0.77) | LMNAMEN1KMT2AMAPTNPSR1 | |
| SCHEMBL3990192 | 0.80 | GPR84 (0.58) | MEN1KMT2AMAPTNPSR1RAB9A | |
| SCHEMBL10172506 | 0.77 | CPS1 (0.47) | LMNAMEN1KMT2ARAB9AALDH1A1 | |
| SCHEMBL3986985 | 0.76 | ABCG2 (0.47) | LMNARAB9ANR4A2ALDH1A1KDM4E | |
| SCHEMBL28386254 | 0.76 | NPSR1 (0.74) | LMNAMEN1KMT2AMAPTNPSR1 | |
| SCHEMBL11794897 | 0.76 | LMNA (0.74) | LMNAMEN1KMT2AMAPTNPSR1 | |
| SCHEMBL21449261 | 0.75 | NR4A2 (0.57) | LMNAMEN1KMT2AMAPTNPSR1 | |
| SCHEMBL592889 | 0.75 | NR4A2 (0.77) | LMNAMEN1KMT2AMAPTNPSR1 | |
| SCHEMBL13302221 | 0.75 | NPSR1 (0.72) | LMNAMEN1KMT2AMAPTNPSR1 | |
| SCHEMBL3990312 | 0.75 | TDO2 (0.41) | NR4A2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2065382-A1 | CGRP antagonists | Boehringer Ingelheim Pharma GmbH & Co. KG (DE) | 2009-06-03 | — | — | EP | disclosed |
| WO-2009050235-A1 | CGRP ANTAGONISTS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-04-23 | — | — | WO | disclosed |
| WO-2009050235-A1 | CGRP ANTAGONISTS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-04-23 | — | — | WO | disclosed |