Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 6/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.38 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | GAA | P10253 | 3/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3973369 | 0.94 | REN (0.43) | RENMAPTTP53L3MBTL1KDM4E | |
| SCHEMBL3972925 | 0.91 | MAPK1 (0.44) | RENMAPTL3MBTL1ALDH1A1KMT2A | |
| SCHEMBL3973856 | 0.91 | L3MBTL1 (0.47) | RENMAPTL3MBTL1ALDH1A1KMT2A | |
| SCHEMBL3977361 | 0.84 | REN (0.47) | RENKMT2ASMN1; SMN2NPSR1MEN1 | |
| SCHEMBL3968604 | 0.84 | SSTR5 (0.40) | ALDH1A1SMN1; SMN2HTT | |
| SCHEMBL3971901 | 0.84 | SSTR5 (0.43) | REN | |
| SCHEMBL3979346 | 0.83 | REN (0.43) | RENTP53L3MBTL1ALDH1A1KMT2A | |
| SCHEMBL3973033 | 0.83 | SSTR5 (0.42) | MAPT | |
| SCHEMBL3978538 | 0.82 | REN (0.43) | RENTDP1KDM4EGAANPSR1 | |
| SCHEMBL3977612 | 0.82 | SLC6A2 (0.37) | RENTDP1KDM4EALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2054385-A2 | PHENYL, PYRIDINE AND QUINOLINE DERIVATIVES | F. Hoffmann-Roche AG (CH) | 2009-05-06 | — | — | EP | claimed |
| WO-2008019967-A2 | PHENYL, PYRIDINE AND QUINOLINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2008-02-21 | — | — | WO | claimed |
| EP-2054385-A2 | PHENYL, PYRIDINE AND QUINOLINE DERIVATIVES | F. Hoffmann-Roche AG (CH) | 2009-05-06 | — | — | EP | disclosed |
| WO-2008019967-A2 | PHENYL, PYRIDINE AND QUINOLINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2008-02-21 | — | — | WO | disclosed |