SCHEMBL3973369

SCHEMBL3973369

CCOc1cc(CN(c2ccc(C(=O)OC)cn2)C2CCNCC2)ccc1OC

nearest known ligand 0.43

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
REN P00797 3/20 0.43
L3MBTL1 Q9Y468 1/20 0.42
ATM Q13315 1/20 0.39
KDM4E B2RXH2 1/20 0.39
ALDH1A1 P00352 3/20 0.38
SMN1; SMN2 Q16637 3/20 0.38
MAPT P10636 2/20 0.38
NPSR1 Q6W5P4 1/20 0.38
HTT P42858 1/20 0.38
TP53 P04637 1/20 0.37
ROCK2 O75116 1/20 0.37
MBTPS1 Q14703 3/20 0.37
F10 P00742 1/20 0.37
PLAU P00749 1/20 0.37
SLC6A2 P23975 1/20 0.37
SLC6A4 P31645 1/20 0.37
SLC6A3 Q01959 1/20 0.37
KCNH2 Q12809 1/20 0.37
MAPK1 P28482 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3974286 0.94 REN (0.43) RENL3MBTL1ATMKDM4EALDH1A1
SCHEMBL3973856 0.92 L3MBTL1 (0.47) RENL3MBTL1ALDH1A1SMN1; SMN2MAPT
SCHEMBL3972925 0.92 MAPK1 (0.44) RENL3MBTL1ALDH1A1SMN1; SMN2MAPT
SCHEMBL3968604 0.90 SSTR5 (0.40) ALDH1A1SMN1; SMN2HTTMBTPS1SLC6A2
SCHEMBL3979346 0.88 REN (0.43) RENL3MBTL1ATMALDH1A1SMN1; SMN2
SCHEMBL3971319 0.86 REN (0.42) RENL3MBTL1ATMALDH1A1SMN1; SMN2
SCHEMBL3977756 0.85 REN (0.41) RENL3MBTL1ATMKDM4EALDH1A1
SCHEMBL3977361 0.85 REN (0.47) RENSMN1; SMN2NPSR1SLC6A2SLC6A4
SCHEMBL3978538 0.83 REN (0.43) RENKDM4ENPSR1SLC6A2SLC6A4
SCHEMBL3977612 0.83 SLC6A2 (0.37) RENKDM4EALDH1A1SLC6A2SLC6A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2054385-A2 PHENYL, PYRIDINE AND QUINOLINE DERIVATIVES F. Hoffmann-Roche AG (CH) 2009-05-06 EP claimed
WO-2008019967-A2 PHENYL, PYRIDINE AND QUINOLINE DERIVATIVES F. HOFFMANN-LA ROCHE AG (CH) 2008-02-21 WO claimed
EP-2054385-A2 PHENYL, PYRIDINE AND QUINOLINE DERIVATIVES F. Hoffmann-Roche AG (CH) 2009-05-06 EP disclosed
WO-2008019967-A2 PHENYL, PYRIDINE AND QUINOLINE DERIVATIVES F. HOFFMANN-LA ROCHE AG (CH) 2008-02-21 WO disclosed