Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | HTR6 | P50406 | 5/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | CA7 | P43166 | 1/20 | 0.42 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | HTR2C | P28335 | 2/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.38 |
| ▸ | ERN1 | O75460 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL709683 | 0.83 | TSHR (0.62) | TSHRHTTHTR6ALDH1A1KMT2A | |
| SCHEMBL1136581 | 0.79 | TSHR (0.50) | TSHRHTTHTR6ALDH1A1KMT2A | |
| SCHEMBL545481 | 0.78 | HTR6 (0.52) | TSHRHTTHTR6CA12CA1 | |
| SCHEMBL1465085 | 0.77 | CA12 (0.47) | TSHRHTTHTR6ALDH1A1CA12 | |
| SCHEMBL1468205 | 0.77 | CYP2D6 (0.50) | TSHRHTTHTR6ALDH1A1HTR2A | |
| SCHEMBL16494923 | 0.77 | NFE2L2 (0.47) | TSHRHTTHTR6HTR2AHTR2C | |
| SCHEMBL17181361 | 0.75 | HSD11B1 (0.50) | TSHRHTTHTR6ALDH1A1CA12 | |
| SCHEMBL16495124 | 0.75 | HTR2A (0.49) | TSHRHTTHTR6ALDH1A1HTR2A | |
| SCHEMBL3420592 | 0.73 | HSD11B1 (0.52) | TSHRHTR6ALDH1A1CA12CA1 | |
| SCHEMBL28570189 | 0.72 | NPSR1 (0.46) | TSHRHTTHTR6ALDH1A1CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009044147-A1 | INDOLIZINE DERIVATIVES WITH CRTH2 RECEPTOR AFFINITY FOR THE TREATMENT OF INFLAMMATORY DISEASES | ARGENTA DISCOVERY LIMITED (GB) | 2009-04-09 | — | — | WO | disclosed |