Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.62 |
| ▸ | HTT | P42858 | 1/20 | 0.62 |
| ▸ | HTR6 | P50406 | 6/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | THRB | P10828 | 1/20 | 0.48 |
| ▸ | BLM | P54132 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | GFER | P55789 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.40 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.40 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2269853 | 0.85 | ALDH1A1 (0.52) | TSHRHTTALDH1A1KMT2AMEN1 | |
| SCHEMBL3166437 | 0.85 | HTT (0.47) | TSHRHTTHTR6ALDH1A1KMT2A | |
| SCHEMBL1468205 | 0.85 | CYP2D6 (0.50) | TSHRHTTHTR6ALDH1A1KMT2A | |
| SCHEMBL5879758 | 0.85 | CYP2C9 (0.55) | TSHRHTTALDH1A1KMT2AMEN1 | |
| SCHEMBL3974600 | 0.83 | TSHR (0.50) | TSHRHTTHTR6ALDH1A1KMT2A | |
| SCHEMBL1136581 | 0.83 | TSHR (0.50) | TSHRHTTHTR6ALDH1A1KMT2A | |
| SCHEMBL28245639 | 0.83 | HTR6 (0.55) | TSHRHTTHTR6ALDH1A1KMT2A | |
| SCHEMBL26615292 | 0.82 | TSHR (0.61) | TSHRHTTHTR6ALDH1A1KMT2A | |
| SCHEMBL16494906 | 0.81 | NFE2L2 (0.49) | TSHRHTTHTR6ALDH1A1KMT2A | |
| SCHEMBL16494957 | 0.81 | PKM (0.56) | HTTHTR6ALDH1A1LMNAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 84 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5538596-A | Process of making paper | ALLIED COLLOIDS LIMITED (GB) | 1996-07-23 | — | — | US | claimed |
| US-20200352921-A1 | ARYL-SULFONAMIDE AND ARYL-SULFONE DERIVATIVES AS TRPML MODULATORS | CALYGENE BIOTECHNOLGY INC (US) | 2020-11-12 | — | — | US | disclosed |
| CN-106083665-B | A method of using aryl sulfonyl benzaldehyde hydrozone to cyclopropane compound open loop | 太原理工大学 | 2018-08-03 | — | — | CN | disclosed |
| CN-105777781-B | Thiazole [4,5 e] thiophene [2,3 b] pyridine derivatives with fluorescent functional and preparation method thereof | 中山大学 | 2017-11-10 | — | — | CN | disclosed |
| CN-106588935-A | Derivative of tetra-substituted pyrrolo [3,2-b] pyrrole and organic electroluminescence device based on same | 江南大学 | 2017-04-26 | — | — | CN | disclosed |
| CN-106083665-A | A kind of use the aryl sulfonyl benzaldehyde hydrozone method to cyclopropane compound open loop | 太原理工大学 | 2016-11-09 | — | — | CN | disclosed |
| CN-105777781-A | Thiazole[4,5-e]thiophene[2,3-b]pyridine type derivative with fluorescent function and preparation method thereof | 中山大学 | 2016-07-20 | — | — | CN | disclosed |
| WO-2016019588-A1 | OXACAZONE COMPOUNDS TO TREAT CLOSTRIDIUM DIFFICILE | THE BROAD INSTITUTE, INC. (US) | 2016-02-11 | — | — | WO | disclosed |
| CN-102822163-B | Crth2 modulators | IRONWOOD PHARMACEUTICALS, INC. (US) | 2016-01-20 | — | — | CN | disclosed |
| EP-1859798-B1 | N-(2-ARYLETHYL) BENZYLAMINES AS ANTAGONISTS OF THE 5-HT6 RECEPTOR | LILLY CO ELI (US) | 2015-12-30 | — | — | EP | disclosed |
| EP-1379239-B1 | N-(2-ARYLETHYL) BENZYLAMINES AS ANTAGONISTS OF THE 5-HT6 RECEPTOR | LILLY CO ELI (US) | 2007-09-12 | — | — | EP | disclosed |
| CN-101014565-A | Diarylsulfones as 5-HT2a antagonists | MERCK SHARP & DOHME (GB) | 2007-08-08 | — | — | CN | disclosed |
| EP-1807393-A1 | DIARYLSULFONES AS 5-HT2A ANTAGONISTS | Merck Sharp & Dohme Limited (GB) | 2007-07-18 | — | — | EP | disclosed |
| US-20070099909-A1 | N-(2-ARYLETHYL)BENZYLAMINES AS ANTAGONISTS OF THE 5-HT6 RECEPTOR | CHEN ZHAOGEN | 2007-05-03 | — | — | US | disclosed |
| US-7157488-B2 | N-(2-Arylethyl) benzylamines as antagonists of the 5-HT6 receptor | ELI LILLY AND COMPANY (US) | 2007-01-02 | — | — | US | disclosed |
| WO-2006021805-A1 | DIARYLSULFONES AS 5-HT2A ANTAGONISTS | MERCK SHARP & DOHME LIMITED (GB) | 2006-03-02 | — | — | WO | disclosed |
| US-20060009511-A9 | N-(2-arylethyl) benzylamines as antagonists of the 5-ht6 receptor | CHEN ZHAOGEN | 2006-01-12 | — | — | US | disclosed |
| CN-1610547-A | N-(2-arylethyl)benzylamines as antagonists of the 5-HT6 receptor | LILLY CO ELI (US) | 2005-04-27 | — | — | CN | disclosed |
| EP-1379239-A2 | N-(2-ARYLETHYL) BENZYLAMINES AS ANTAGONISTS OF THE 5-HT6 RECEPTOR | ELI LILLY AND COMPANY (US) | 2004-01-14 | — | — | EP | disclosed |
| WO-2002078693-A2 | N-(2-ARYLETHYL)BENZYLAMINES AS ANTAGONISTS OF THE 5-HT6 RECEPTOR | ELI LILLY AND COMPANY (US) | 2002-10-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200352921-A1 | ARYL-SULFONAMIDE AND ARYL-SULFONE DERIVATIVES AS TRPML MODULATORS | TRPM6, TRPM2, TRPM5 | TSHR 2088/4885HTT 1942/4885HTR6 1250/4885 |
| US-20060009511-A9 | N-(2-arylethyl) benzylamines as antagonists of the 5-ht6 receptor | HTR6, HTR2C, HTR1B | TSHR 286/4885HTT 465/4885HTR6 1/4885 |
| US-20070099909-A1 | N-(2-ARYLETHYL)BENZYLAMINES AS ANTAGONISTS OF THE 5-HT6 RECEPTOR | HTR6, HTR2C, HTR1B | TSHR 286/4885HTT 465/4885HTR6 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.